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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-2912-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:BCG_2872c
OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
Taxonomic identifieri410289 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001472 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable malate:quinone oxidoreductasePRO_1000023807Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1KMJ5.
SMRiA1KMJ5. Positions 9-43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A1KMJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP
60 70 80 90 100
WNNAGTGHSA LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN
110 120 130 140 150
GILTDVRSFL NPVPHVSFVH GSRGVEYLRR RQKALAGNPL FAGTEFIESP
160 170 180 190 200
DEFARRLPFM AAKRAFSEPV ALNWAADGTD VDFGALAKQL IGYCVQNGTT
210 220 230 240 250
ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV GAGGDTLPVL
260 270 280 290 300
QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL
310 320 330 340 350
HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG
360 370 380 390 400
LTERRLLNYL ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR
410 420 430 440 450
RDERNGGVLE FGTTVIGDAD GSIAGLLGGS PGASTAVAIM LDVLQKCFAN
460 470 480 490
RYQSWLPTLK EMVPSLGVQL SNEPALFDEV WSWSTKALKL GAA
Length:493
Mass (Da):53,595
Last modified:February 6, 2007 - v1
Checksum:iC3B4C469FF4F285F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL72861.1.
RefSeqiWP_003414545.1. NC_008769.1.

Genome annotation databases

EnsemblBacteriaiCAL72861; CAL72861; BCG_2872c.
KEGGimbb:BCG_2872c.
PATRICi18016766. VBIMycBov80988_3129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL72861.1.
RefSeqiWP_003414545.1. NC_008769.1.

3D structure databases

ProteinModelPortaliA1KMJ5.
SMRiA1KMJ5. Positions 9-43.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL72861; CAL72861; BCG_2872c.
KEGGimbb:BCG_2872c.
PATRICi18016766. VBIMycBov80988_3129.

Phylogenomic databases

HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciMBOV410289:GJW7-2912-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO_MYCBP
AccessioniPrimary (citable) accession number: A1KMJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.