A1KM16 (DCUP_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	BCG_2691c

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023920
Regions
	Region	30 – 34	5	Substrate binding By similarity
Sites
	Binding site	79	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	336	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1KM16 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F5F09F1680BDC7B3	FASTA	357	37,606
	10 20 30 40 50 60 MSTRRDLPQS PYLAAVTGRK PSRVPVWFMR QAGRSLPEYR ALRERYSMLA ACFEPDVACE 70 80 90 100 110 120 ITLQPIRRYD VDAAILFSDI VVPLRAAGVD LDIVADVGPV IADPVRTAAD VAAMKPLDPQ 130 140 150 160 170 180 AIQPVLVAAS LLVAELGDVP LIGFAGAPFT LASYLVEGGP SRHHAHVKAM MLAEPASWHA 190 200 210 220 230 240 LMAKLTDLTI AFLVGQIDAG VDAIQVFDSW AGALSPIDYR QYVLPHSARV FAALGEHGVP 250 260 270 280 290 300 MTHFGVGTAE LLGAMSEAVT AGERPGRGAV VGVDWRTPLT DAAARVVPGT ALQGNLDPAV 310 320 330 340 350 VLAGWPAVER AARAVVDDGR RAVDAGAAGH IFNLGHGVLP ESDPAVLADL VSLVHSL

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BCG / Pasteur 1173P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL72679.1.
RefSeq	YP_978777.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KM16.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KM16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000021494; EBMYCP00000021244; EBMYCG00000021489.
GeneID	4698931.
GenomeReviews	Gene locus BCG_2691c in contig AM408590_GR.
KEGG	mbb:BCG_2691c.
PATRIC	18016372. VBIMycBov80988_2932.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
GeneTree	EBGT00050000016469.
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	MBOV410289:BCG_2691C-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_MYCBP

Accession

Primary (citable) accession number: A1KM16

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program