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A1KLS8 (SYH_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:BCG_2603c
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_1000016396

Sequences

Sequence LengthMass (Da)Tools
A1KLS8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C85FBA7B1C7D607F

FASTA42345,149
        10         20         30         40         50         60 
MTEFSSFSAP KGVPDYVPPD SAQFVAVRDG LLAAARQAGY SHIELPIFED TALFARGVGE 

        70         80         90        100        110        120 
STDVVSKEMY TFADRGDRSV TLRPEGTAGV VRAVIEHGLD RGALPVKLCY AGPFFRYERP 

       130        140        150        160        170        180 
QAGRYRQLQQ VGVEAIGVDD PALDAEVIAI ADAGFRSLGL DGFRLEITSL GDESCRPQYR 

       190        200        210        220        230        240 
ELLQEFLFGL DLDEDTRRRA GINPLRVLDD KRPELRAMTA SAPVLLDHLS DVAKQHFDTV 

       250        260        270        280        290        300 
LAHLDALGVP YVINPRMVRG LDYYTKTAFE FVHDGLGAQS GIGGGGRYDG LMHQLGGQDL 

       310        320        330        340        350        360 
SGIGFGLGVD RTVLALRAEG KTAGDSARCD VFGVPLGEAA KLRLAVLAGR LRAAGVRVDL 

       370        380        390        400        410        420 
AYGDRGLKGA MRAAARSGAR VALVAGDRDI EAGTVAVKDL TTGEQVSVSM DSVVAEVISR 


LAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL72591.1.
RefSeqYP_978689.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KLS8.
SMRA1KLS8. Positions 31-422.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410289.BCG_2603c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL72591; CAL72591; BCG_2603c.
GeneID4696840.
KEGGmbb:BCG_2603c.
PATRIC18016190. VBIMycBov80988_2845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018072.
KOK01892.
OMACGGGNFK.
OrthoDBEOG6BPDH4.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-2639-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_MYCBP
AccessionPrimary (citable) accession number: A1KLS8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries