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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. histidine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-2639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:BCG_2603c
OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
Taxonomic identifieri410289 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001472 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Histidine--tRNA ligasePRO_1000016396Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi410289.BCG_2603c.

Structurei

3D structure databases

ProteinModelPortaliA1KLS8.
SMRiA1KLS8. Positions 31-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KLS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFSSFSAP KGVPDYVPPD SAQFVAVRDG LLAAARQAGY SHIELPIFED
60 70 80 90 100
TALFARGVGE STDVVSKEMY TFADRGDRSV TLRPEGTAGV VRAVIEHGLD
110 120 130 140 150
RGALPVKLCY AGPFFRYERP QAGRYRQLQQ VGVEAIGVDD PALDAEVIAI
160 170 180 190 200
ADAGFRSLGL DGFRLEITSL GDESCRPQYR ELLQEFLFGL DLDEDTRRRA
210 220 230 240 250
GINPLRVLDD KRPELRAMTA SAPVLLDHLS DVAKQHFDTV LAHLDALGVP
260 270 280 290 300
YVINPRMVRG LDYYTKTAFE FVHDGLGAQS GIGGGGRYDG LMHQLGGQDL
310 320 330 340 350
SGIGFGLGVD RTVLALRAEG KTAGDSARCD VFGVPLGEAA KLRLAVLAGR
360 370 380 390 400
LRAAGVRVDL AYGDRGLKGA MRAAARSGAR VALVAGDRDI EAGTVAVKDL
410 420
TTGEQVSVSM DSVVAEVISR LAG
Length:423
Mass (Da):45,149
Last modified:February 6, 2007 - v1
Checksum:iC85FBA7B1C7D607F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL72591.1.
RefSeqiYP_978689.1. NC_008769.1.

Genome annotation databases

EnsemblBacteriaiCAL72591; CAL72591; BCG_2603c.
KEGGimbb:BCG_2603c.
PATRICi18016190. VBIMycBov80988_2845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL72591.1.
RefSeqiYP_978689.1. NC_008769.1.

3D structure databases

ProteinModelPortaliA1KLS8.
SMRiA1KLS8. Positions 31-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi410289.BCG_2603c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL72591; CAL72591; BCG_2603c.
KEGGimbb:BCG_2603c.
PATRICi18016190. VBIMycBov80988_2845.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-2639-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCG / Pasteur 1173P2.

Entry informationi

Entry nameiSYH_MYCBP
AccessioniPrimary (citable) accession number: A1KLS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.