A1KLC4 (AHPD_MYCBP) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alkyl hydroperoxide reductase AhpD EC=1.11.1.15 Alternative name(s): Alkylhydroperoxidase AhpD | ||||
| Gene names |
| ||||
| Organism | Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 410289 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 177 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676 |
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676 |
| Subunit structure | Homotrimer By similarity. HAMAP MF_01676 |
| Sequence similarities | Belongs to the AhpD family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Redox-active center |
| Molecular function | Antioxidant Oxidoreductase Peroxidase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 177 | 177 | Alkyl hydroperoxide reductase AhpD HAMAP MF_01676 | PRO_0000359497 | |||||||
Sites | |||||||||||
| Active site | 130 | 1 | Proton donor By similarity | ||||||||
| Active site | 133 | 1 | Cysteine sulfenic acid (-SOH) intermediate By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 130 ↔ 133 | Alternate By similarity | |||||||||
| Disulfide bond | 133 | Interchain (with AhpC); in linked form By similarity | |||||||||
Sequences
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References
| [1] | "Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BCG / Pasteur 1173P2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM408590 Genomic DNA. Translation: CAL72436.1. |
| RefSeq | YP_978535.1. NC_008769.1. |
3D structure databases | |
| ProteinModelPortal | A1KLC4. |
| SMR | A1KLC4. Positions 2-175. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1KLC4. |
Protein family/group databases | |
| PeroxiBase | 4579. MboAhpD_BCG. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000019359; EBMYCP00000019109; EBMYCG00000019354. |
| GeneID | 4695782. |
| GenomeReviews | Gene locus BCG_2448 in contig AM408590_GR. |
| KEGG | mbb:BCG_2448. |
| PATRIC | 18015840. VBIMycBov80988_2676. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG2128. |
| GeneTree | EBGT00050000016698. |
| HOGENOM | HBG414634. |
| OMA | RAGLRMN. |
| ProtClustDB | CLSK791846. |
Enzyme and pathway databases | |
| BioCyc | MBOV410289:BCG_2448-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01676. AhpD. [Tree] |
| InterPro | IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view] |
| KO | K04756. |
| Pfam | PF02627. CMD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AHPD_MYCBP | ||||||||
| Accession | Primary (citable) accession number: A1KLC4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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