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A1KL82 (CYSH_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoadenosine phosphosulfate reductase

EC=1.8.4.8
Alternative name(s):
3'-phosphoadenylylsulfate reductase
PAPS reductase, thioredoxin dependent
PAPS sulfotransferase
PAdoPS reductase
Gene names
Name:cysH
Ordered Locus Names:BCG_2406
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of activated sulfate into sulfite By similarity. HAMAP-Rule MF_00063

Catalytic activity

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP-Rule MF_00063

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP-Rule MF_00063

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Phosphoadenosine phosphosulfate reductase HAMAP-Rule MF_00063
PRO_1000008929

Sequences

Sequence LengthMass (Da)Tools
A1KL82 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 554F2E3204452C55

FASTA25427,423
        10         20         30         40         50         60 
MSGETTRLTE PQLRELAARG AAELDGATAT DMLRWTDETF GDIGGAGGGV SGHRGWTTCN 

        70         80         90        100        110        120 
YVVASNMADA VLVDLAAKVR PGVPVIFLDT GYHFVETIGT RDAIESVYDV RVLNVTPEHT 

       130        140        150        160        170        180 
VAEQDELLGK DLFARNPHEC CRLRKVVPLG KTLRGYSAWV TGLRRVDAPT RANAPLVSFD 

       190        200        210        220        230        240 
ETFKLVKVNP LAAWTDQDVQ EYIADNDVLV NPLVREGYPS IGCAPCTAKP AEGADPRSGR 

       250 
WQGLAKTECG LHAS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL72394.1.
RefSeqYP_978495.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KL82.
SMRA1KL82. Positions 21-241.
ModBaseSearch...

Protein-protein interaction databases

STRING410289.BCG_2406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL72394; CAL72394; BCG_2406.
GeneID4699205.
KEGGmbb:BCG_2406.
PATRIC18015742. VBIMycBov80988_2627.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0175.
HOGENOMHOG000249397.
KOK00390.
OMAFLSVGCM.
ProtClustDBPRK02090.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-2437-MONOMER.
UniPathwayUPA00140; UER00206.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00063. CysH.
InterProIPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.
ProtoNetSearch...

Other

BindingDBA1KL82.

Entry information

Entry nameCYSH_MYCBP
AccessionPrimary (citable) accession number: A1KL82
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families