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A1KKH9 (UPPP_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:BCG_2153c
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290729

Regions

Transmembrane84 – 10421Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane250 – 27021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1KKH9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 2D8BE04F41D35668

FASTA27629,733
        10         20         30         40         50         60 
MSWWQVIVLA AAQGLTEFLP VSSSGHLAIV SRIFFSGDAG ASFTAVSQLG TEAAVVIYFA 

        70         80         90        100        110        120 
RDIVRILSAW LHGLVVKAHR NTDYRLGWYV IIGTIPICIL GLFFKDDIRS GVRNLWVVVT 

       130        140        150        160        170        180 
ALVVFSGVIA LAEYVGRQSR HIERLTWRDA VVVGIAQTLA LVPGVSRSGS TISAGLFLGL 

       190        200        210        220        230        240 
DRELAARFGF LLAIPAVFAS GLFSLPDAFH PVTEGMSATG PQLLVATLIA FVLGLTAVAW 

       250        260        270 
LLRFLVRHNM YWFVGYRVLV GTGMLVLLAT GTVAAT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL72141.1.
RefSeqYP_978242.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KKH9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410289.BCG_2153c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL72141; CAL72141; BCG_2153c.
GeneID4699319.
KEGGmbb:BCG_2153c.
PATRIC18015186. VBIMycBov80988_2354.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-2179-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCBP
AccessionPrimary (citable) accession number: A1KKH9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families