A1KJE8 (GABD2_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative succinate-semialdehyde dehydrogenase [NADP+] 2
Short name=SSADH 2
Short name=SSDH 2
EC=1.2.1.79

Gene names

Name:	gabD2
Ordered Locus Names:	BCG_1770

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.
Catalytic activity	Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Putative succinate-semialdehyde dehydrogenase [NADP+] 2		PRO_0000310709
Regions
	Nucleotide binding	157 – 158	2	NADP By similarity
	Nucleotide binding	181 – 184	4	NADP By similarity
	Nucleotide binding	232 – 233	2	NADP By similarity
Sites
	Active site	254	1	Proton acceptor By similarity
	Active site	288	1	Nucleophile By similarity
	Binding site	255	1	NADP; via carbonyl oxygen By similarity
	Binding site	386	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1KJE8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E3AC9E895EB46270	FASTA	518	55,324
	10 20 30 40 50 60 MPAPSAEVFD RLRNLAAIKD VAARPTRTID EVFTGKPLTT IPVGTAADVE AAFAEARAAQ 70 80 90 100 110 120 TDWAKRPVIE RAAVIRRYRD LVIENREFLM DLLQAEAGKA RWAAQEEIVD LIANANYYAR 130 140 150 160 170 180 VCVDLLKPRK AQPLLPGIGK TTVCYQPKGV VGVISPWNYP MTLTVSDSVP ALVAGNAVVL 190 200 210 220 230 240 KPDSQTPYCA LACAELLYRA GLPRALYAIV PGPGSVVGTA ITDNCDYLMF TGSSATGSRL 250 260 270 280 290 300 AEHAGRRLIG FSAELGGKNP MIVARGANLD KVAKAATRAC FSNAGQLCIS IERIYVEKDI 310 320 330 340 350 360 AEEFTRKFGD AVRNMKLGTA YDFSVDMGSL ISEAQLKTVS GHVDDATAKG AKVIAGGKAR 370 380 390 400 410 420 PDIGPLFYEP TVLTNVAPEM ECAANETFGP VVSIYPVADV DEAVEKANDT DYGLNASVWA 430 440 450 460 470 480 GSTAEGQRIA ARLRSGTVNV DEGYAFAWGS LSAPMGGMGL SGVGRRHGPE GLLKYTESQT 490 500 510 IATARVFNLD PPFGIPATVW QKSLLPIVRT VMKLPGRR

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BCG / Pasteur 1173P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71757.1.
RefSeq	YP_977862.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KJE8.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KJE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000019661; EBMYCP00000019411; EBMYCG00000019656.
GeneID	4697644.
GenomeReviews	Gene locus BCG_1770 in contig AM408590_GR.
KEGG	mbb:BCG_1770.
PATRIC	18014340. VBIMycBov80988_1930.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
GeneTree	EBGT00050000015660.
HOGENOM	HBG752218.
OMA	GPLVSIY.
ProtClustDB	PRK09407.
Enzyme and pathway databases
BioCyc	MBOV410289:BCG_1770-MONOMER.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00135.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD2_MYCBP

Accession

Primary (citable) accession number: A1KJE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program