A1KJD0 (DER_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Der

Alternative name(s):
GTP-binding protein EngA

Gene names

Name:	der
Synonyms:	engA
Ordered Locus Names:	BCG_1752

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195
Subunit structure	Associates with the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. Contains 2 G (guanine nucleotide-binding) domains. Contains 1 KH-like domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	GTPase Der HAMAP MF_00195		PRO_1000011668
Regions
	Domain	38 – 143	106	G 1
	Domain	211 – 319	109	G 2
	Domain	373 – 456	84	KH-like
	Nucleotide binding	33 – 40	8	GTP 1 Potential
	Nucleotide binding	80 – 84	5	GTP 1 Potential
	Nucleotide binding	142 – 145	4	GTP 1 Potential
	Nucleotide binding	206 – 213	8	GTP 2 Potential
	Nucleotide binding	253 – 257	5	GTP 2 Potential
	Nucleotide binding	318 – 321	4	GTP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	A1KJD0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 9FBDEA105C6E99C8	FASTA	463	49,958
	10 20 30 40 50 60 MTQDGTWVDE SDWQLDDSEI AESGAAPVVA VVGRPNVGKS TLVNRILGRR EAVVQDIPGV 70 80 90 100 110 120 TRDRVCYDAL WTGRRFVVQD TGGWEPNAKG LQRLVAEQAS VAMRTADAVI LVVDAGVGAT 130 140 150 160 170 180 AADEAAARIL LRSGKPVFLA ANKVDSEKGE SDAAALWSLG LGEPHAISAM HGRGVADLLD 190 200 210 220 230 240 GVLAALPEVG ESASASGGPR RVALVGKPNV GKSSLLNKLA GDQRSVVHEA AGTTVDPVDS 250 260 270 280 290 300 LIELGGDVWR FVDTAGLRRK VGQASGHEFY ASVRTHAAID SAEVAIVLID ASQPLTEQDL 310 320 330 340 350 360 RVISMVIEAG RALVLAYNKW DLVDEDRREL LQREIDRELV QVRWAQRVNI SAKTGRAVHK 370 380 390 400 410 420 LVPAMEDALA SWDTRIATGP LNTWLTEVTA ATPPPVRGGK QPRILFATQA TARPPTFVLF 430 440 450 460 TTGFLEAGYR RFLERRLRET FGFDGSPIRV NVRVREKRAG KRR

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BCG / Pasteur 1173P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71739.1.
RefSeq	YP_977844.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KJD0.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KJD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000021945; EBMYCP00000021695; EBMYCG00000021940.
GeneID	4698565.
GenomeReviews	Gene locus BCG_1752 in contig AM408590_GR.
KEGG	mbb:BCG_1752.
PATRIC	18014296. VBIMycBov80988_1909.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1160.
GeneTree	EBGT00050000016947.
HOGENOM	HBG592135.
OMA	QGADFYA.
ProtClustDB	PRK03003.
Enzyme and pathway databases
BioCyc	MBOV410289:BCG_1752-MONOMER.
Family and domain databases
HAMAP	MF_00195. GTPase_Der. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR016484. GTP-bd_EngA. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03977.
PANTHER	PTHR11649:SF5. PTHR11649:SF5. 1 hit.
Pfam	PF01926. MMR_HSR1. 2 hits. [Graphical view]
PIRSF	PIRSF006485. GTP-binding_EngA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR03594. GTPase_EngA. 1 hit. TIGR00231. Small_GTP. 2 hits.
ProtoNet	Search...

Entry information

Entry name

DER_MYCBP

Accession

Primary (citable) accession number: A1KJD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program