A1KJB1 (A1KJB1_MYCBP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361
Short name=Poly(P)/ATP NAD kinase HAMAP MF_00361
EC=2.7.1.23 HAMAP MF_00361

Gene names

Name:	ppnK HAMAP MF_00361 EMBL CAL71720.1
Ordered Locus Names:	BCG_1733

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361 SAAS SAAS002504
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361 SAAS SAAS002504
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361 SAAS SAAS002504
Subcellular location	Cytoplasm By similarity HAMAP MF_00361 SAAS SAAS002504.
Sequence similarities	Belongs to the NAD kinase family. HAMAP MF_00361

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00361 SAAS SAAS002504
Ligand	ATP-binding HAMAP MF_00361 SAAS SAAS002504 NAD HAMAP MF_00361 SAAS SAAS002504 NADP HAMAP MF_00361 SAAS SAAS002504 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00361 SAAS SAAS002504 EMBL CAL71720.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1KJB1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 68817BE570B6645B	FASTA	307	32,904
	10 20 30 40 50 60 MTAHRSVLLV VHTGRDEATE TARRVEKVLG DNKIALRVLS AEAVDRGSLH LAPDDMRAMG 70 80 90 100 110 120 VEIEVVDADQ HAADGCELVL VLGGDGTFLR AAELARNASI PVLGVNLGRI GFLAEAEAEA 130 140 150 160 170 180 IDAVLEHVVA QDYRVEDRLT LDVVVRQGGR IVNRGWALNE VSLEKGPRLG VLGVVVEIDG 190 200 210 220 230 240 RPVSAFGCDG VLVSTPTGST AYAFSAGGPV LWPDLEAILV VPNNAHALFG RPMVTSPEAT 250 260 270 280 290 300 IAIEIEADGH DALVFCDGRR EMLIPAGSRL EVTRCVTSVK WARLDSAPFT DRLVRKFRLP VTGWRGK

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71720.1.
RefSeq	YP_977825.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KJB1.
SMR	A1KJB1. Positions 2-305.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KJB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000019920; EBMYCP00000019670; EBMYCG00000019915.
GeneID	4696386.
GenomeReviews	Gene locus BCG_1733 in contig AM408590_GR.
KEGG	mbb:BCG_1733.
PATRIC	18014254. VBIMycBov80988_1888.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000016530.
HOGENOM	HBG713904.
OMA	GPVVWPE.
ProtClustDB	PRK03372.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1KJB1_MYCBP

Accession

Primary (citable) accession number: A1KJB1

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)