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A1KIK5 (A1KIK5_MYCBP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
Short name=DMRL synthase HAMAP MF_00178
Short name=Lumazine synthase HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178
Alternative name(s):
Riboflavin synthase beta chain HAMAP MF_00178
Gene names
Name:ribH HAMAP MF_00178 EMBL CAL71464.1
Ordered Locus Names:BCG_1477
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178 RuleBase RU003795

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178 RuleBase RU003795

Sequence similarities

Belongs to the DMRL synthase family. HAMAP MF_00178 RuleBase RU003795

Sequences

Sequence LengthMass (Da)Tools
A1KIK5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: B10283E900683696

FASTA15415,901
        10         20         30         40         50         60 
MPDLPSLDAS GVRLAIVASS WHGKICDALL DGARKVAAGC GLDDPTVVRV LGAIEIPVVA 

        70         80         90        100        110        120 
QELARNHDAV VALGVVIRGQ TPHFDYVCDA VTQGLTRVSL DSSTPIANGV LTTNTEEQAL 

       130        140        150 
DRAGLPTSAE DKGAQATVAA LATALTLREL RAHS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM408590 Genomic DNA. Translation: CAL71464.1.
RefSeqYP_977569.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KIK5.
SMRA1KIK5. Positions 4-154.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1KIK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000019210; EBMYCP00000018960; EBMYCG00000019205.
GeneID4696889.
GenomeReviewsGene locus BCG_1477 in contig AM408590_GR.
KEGGmbb:BCG_1477.
PATRIC18013710. VBIMycBov80988_1616.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0054.
GeneTreeEBGT00050000016935.
HOGENOMHBG311126.
OMASSRALMD.
ProtClustDBPRK00061.

Family and domain databases

HAMAPMF_00178. Lumazine_synth.
[Tree]
InterProIPR002180. DMRL_synthase.
[Graphical view]
Gene3DG3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KOK00794.
PANTHERPTHR21058. DMRL_synthase. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. Lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1KIK5_MYCBP
AccessionPrimary (citable) accession number: A1KIK5
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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