A1KIH8 (A1KIH8_MYCBP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable guanylate kinase gmk EMBL CAL71437.1
EC=2.7.4.8 EMBL CAL71437.1

Gene names

Name:	gmk EMBL CAL71437.1
Ordered Locus Names:	BCG_1450

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. SAAS SAAS020590
Catalytic activity	ATP + GMP = ADP + GDP. SAAS SAAS020590
Subcellular location	Cytoplasm By similarity SAAS SAAS020590.
Sequence similarities	Contains 1 guanylate kinase-like domain. SAAS SAAS017665

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS020590
Ligand	ATP-binding SAAS SAAS020590 Nucleotide-binding
Molecular function	Kinase SAAS SAAS020590 EMBL CAL71437.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1KIH8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 3D2948315974549F	FASTA	208	22,095
	10 20 30 40 50 60 MSVGEGPDTK PTARGQPAAV GRVVVLSGPS AVGKSTVVRC LRERIPNLHF SVSATTRAPR 70 80 90 100 110 120 PGEVDGVDYH FIDPTRFQQL IDQGELLEWA EIHGGLHRSG TLAQPVRAAA ATGVPVLIEV 130 140 150 160 170 180 DLAGARAIKK TMPEAVTVFL APPSWQDLQA RLIGRGTETA DVIQRRLDTA RIELAAQGDF 190 200 DKVVVNRRLE SACAELVSLL VGTAPGSP

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71437.1.
RefSeq	YP_977542.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KIH8.
SMR	A1KIH8. Positions 20-202.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KIH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000021459; EBMYCP00000021209; EBMYCG00000021454.
GeneID	4699003.
GenomeReviews	Gene locus BCG_1450 in contig AM408590_GR.
KEGG	mbb:BCG_1450.
PATRIC	18013656. VBIMycBov80988_1589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
GeneTree	EBGT00050000017746.
HOGENOM	HBG671982.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
KO	K00942.
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1KIH8_MYCBP

Accession

Primary (citable) accession number: A1KIH8

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)