A1KHX7 (A1KHX7_MYCBP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable pyrroline-5-carboxylate dehydrogenase rocA EMBL CAL71236.1
EC=1.5.1.12 EMBL CAL71236.1

Gene names

Name:	rocA EMBL CAL71236.1
Ordered Locus Names:	BCG_1249

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RuleBase RU003345

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU003344 EMBL CAL71236.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: InterPro
Molecular function	1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1KHX7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 61454C51BDD42D9C	FASTA	543	58,841
	10 20 30 40 50 60 MDAITQVPVP ANEPVHDYAP KSPERTRLRT ELASLADHPI DLPHVIGGRH RMGDGERIDV 70 80 90 100 110 120 VQPHRHAARL GTLTNATHAD AAAAVEAAMS AKSDWAALPF DERAAVFLRA ADLLAGPWRE 130 140 150 160 170 180 KIAAATMLGQ SKSVYQAEID AVCELIDFWR FNVAFARQIL EQQPISGPGE WNRIDYRPLD 190 200 210 220 230 240 GFVYAITPFN FTSIAGNLPT APALMGNTVI WKPSITQTLA AYLTMQLLEA AGLPPGVINL 250 260 270 280 290 300 VTGDGFAVSD VALADPRLAG IHFTGSTATF GHLWQWVGTN IGRYHSYPRL VGETGGKDFV 310 320 330 340 350 360 VAHASARPDV LRTALIRGAF DYQGQKCSAV SRAFIAHSVW QRMGDELLAK AAELRYGDIT 370 380 390 400 410 420 DLSNYGGALI DQRAFVKNVD AIERAKGAAA VTVAVGGEYD DSEGYFVRPT VLLSDDPTDE 430 440 450 460 470 480 SFVIEYFGPL LSVHVYPDER YEQILDVIDT GSRYALTGAV IADDRQAVLT ALDRLRFAAG 490 500 510 520 530 540 NFYVNDKPTG AVVGRQPFGG ARGSGTNDKA GSPLNLLRWT SARSIKETFV AATDHIYPHM AVD

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71236.1.
RefSeq	YP_977341.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KHX7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KHX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000021080; EBMYCP00000020830; EBMYCG00000021075.
GeneID	4697146.
GenomeReviews	Gene locus BCG_1249 in contig AM408590_GR.
KEGG	mbb:BCG_1249.
PATRIC	18013206. VBIMycBov80988_1369.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
GeneTree	EBGT00050000015660.
HOGENOM	HBG752218.
OMA	CELVDFW.
ProtClustDB	CLSK871904.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005931. Delta1-pyrroline-5-COlate_DH-1. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00294.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01236. D1pyr5carbox1. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1KHX7_MYCBP

Accession

Primary (citable) accession number: A1KHX7

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)