A1KHN2 (COAA_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	BCG_1152c

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_1000043226
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1KHN2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F075B543AE75788D	FASTA	312	35,657
	10 20 30 40 50 60 MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWDHH 130 140 150 160 170 180 PRVDLVTTDG FLYPNAELQR RNLMHRKGFP ESYNRRALMR FVTSVKSGSD YACAPVYSHL 190 200 210 220 230 240 HYDIIPGAEQ VVRHPDILIL EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL 250 260 270 280 290 300 AMRTTAFADP ESHFHHYAAF SDSQAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA 310 DHSINRLRLR KL

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BCG / Pasteur 1173P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71139.1.
RefSeq	YP_977246.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KHN2.
SMR	A1KHN2. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KHN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000020477; EBMYCP00000020227; EBMYCG00000020472.
GeneID	4696633.
GenomeReviews	Gene locus BCG_1152c in contig AM408590_GR.
KEGG	mbb:BCG_1152c.
PATRIC	18012986. VBIMycBov80988_1259.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	MBOV410289:BCG_1152C-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCBP

Accession

Primary (citable) accession number: A1KHN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program