A1KHE1 (A1KHE1_MYCBP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase I HAMAP MF_01877
EC=2.1.1.198 HAMAP MF_01877

Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase HAMAP MF_01877
rRNA (cytidine-2'-O-)-methyltransferase RsmI HAMAP MF_01877

Gene names

Name:	rsmI HAMAP MF_01877
Ordered Locus Names:	BCG_1060

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA By similarity. HAMAP MF_01877
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytosine(1402) in 16S rRNA. HAMAP MF_01877
Subcellular location	Cytoplasm By similarity HAMAP MF_01877.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmI family. HAMAP MF_01877

Ontologies

Keywords
Biological process	rRNA processing HAMAP MF_01877
Cellular component	Cytoplasm HAMAP MF_01877
Ligand	S-adenosyl-L-methionine HAMAP MF_01877
Molecular function	Methyltransferase HAMAP MF_01877 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	enzyme-directed rRNA 2'-O-methylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rRNA (cytosine-2'-O-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1KHE1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 2F799A8057F64634	FASTA	285	29,665
	10 20 30 40 50 60 MSSGRLLLGA TPLGQPSDAS PRLAAALATA DVVAAEDTRR VRKLAKALDI RIGGRVVSLF 70 80 90 100 110 120 DRVEALRVTA LLDAINNGAT VLVVSDAGTP VISDPGYRLV AACIDAGVSV TCLPGPSAVT 130 140 150 160 170 180 TALVMSGLPA EKFCFEGFAP RKGAARRAWL AELAEERRTC VFFESPRRLA ACLNDAVEQL 190 200 210 220 230 240 GGARPAAICR ELTKVHEEVV RGSLDELAIW AAGGVLGEIT VVVAGAAPHA ELSSLIAQVE 250 260 270 280 EFVAAGIRVK DACSEVAAAH PGVRTRQLYD AVLQSRRETG GPAQP

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL71047.1.
RefSeq	YP_977155.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KHE1.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KHE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000018735; EBMYCP00000018485; EBMYCG00000018730.
GeneID	4696619.
GenomeReviews	Gene locus BCG_1060 in contig AM408590_GR.
KEGG	mbb:BCG_1060.
PATRIC	18012770. VBIMycBov80988_1153.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0313.
GeneTree	EBGT00050000017256.
HOGENOM	HBG529058.
OMA	IASDRFC.
ProtClustDB	CLSK790887.
Family and domain databases
HAMAP	MF_01877. 16SrRNA_methyltr_I. [Tree]
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR008189. rRNA_ssu_MeTfrase_I. IPR018063. SAM_MeTrfase_RsmI_CS. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit. G3DSA:3.30.950.10. 4pyrrole_Mease_sub2. 1 hit.
KO	K07056.
PANTHER	PTHR21091:SF18. PTHR21091:SF18. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF005917. MTase_YraL. 1 hit.
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMs	TIGR00096. TIGR00096. 1 hit.
PROSITE	PS01296. RSMI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1KHE1_MYCBP

Accession

Primary (citable) accession number: A1KHE1

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)