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A1KHB7 (MPRA_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene names
Name:mprA
Ordered Locus Names:BCG_1036
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated and dephosphorylated by MprB By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Response regulator MprA
PRO_0000308420

Regions

Domain4 – 118115Response regulatory

Amino acid modifications

Modified residue4814-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1KHB7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C35D0734555BFC1C

FASTA23025,924
        10         20         30         40         50         60 
MSVRILVVDD DRAVRESLRR SLSFNGYSVE LAHDGVEALD MIASDRPDAL VLDVMMPRLD 

        70         80         90        100        110        120 
GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY LPKPFALEEL LARMRALLRR 

       130        140        150        160        170        180 
TKPEDAAESM AMRFSDLTLD PVTREVNRGQ RRISLTRTEF ALLEMLIANP RRVLTRSRIL 

       190        200        210        220        230 
EEVWGFDFPT SGNALEVYVG YLRRKTEADG EPRLIHTVRG VGYVLRETPP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL71023.1.
RefSeqYP_977131.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KHB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410289.BCG_1036.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL71023; CAL71023; BCG_1036.
GeneID4697720.
KEGGmbb:BCG_1036.
PATRIC18012720. VBIMycBov80988_1129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07669.
OMAWLRDGVS.
OrthoDBEOG6G4VQG.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-1053-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPRA_MYCBP
AccessionPrimary (citable) accession number: A1KHB7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families