A1KGU2 (A1KGU2_MYCBP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Name:	purM EMBL CAL70847.1
Ordered Locus Names:	BCG_0861

Organism

Mycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]

Taxonomic identifier

410289 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733 EMBL CAL70847.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1KGU2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 9ECF162DE6C59A92	FASTA	364	38,393
	10 20 30 40 50 60 MTDLAKGPGK DPGSRGITYA SAGVDIEAGD RAIDLFKPLA SKATRPEVRG GLGGFAGLFT 70 80 90 100 110 120 LRGDYREPVL AASSDGVGTK LAIAQAMDKH DTVGLDLVAM VVDDLVVCGA EPLFLLDYIA 130 140 150 160 170 180 VGRIVPERLS AIVAGIADGC MRAGCALLGG ETAEHPGLIE PDHYDISATG VGVVEADNVL 190 200 210 220 230 240 GPDRVKPGDV IIAMGSSGLH SNGYSLVRKV LLEIDRMNLA GHVEEFGRTL GEELLEPTRI 250 260 270 280 290 300 YAKDCLALAA ETRVRTFCHV TGGGLAGNLQ RVIPHGLIAE VDRGTWTPAP VFTMIAQRGR 310 320 330 340 350 360 VRRTEMEKTF NMGVGMIAVV APEDTTRALA VLTARHLDCW VLGTVCKGGK QGPRAKLVGQ HPRF

References

[1]

"Genome plasticity of BCG and impact on vaccine efficacy." Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007) [PubMed: 17372194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM408590 Genomic DNA. Translation: CAL70847.1.
RefSeq	YP_976956.1. NC_008769.1.
3D structure databases
ProteinModelPortal	A1KGU2.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KGU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000018962; EBMYCP00000018712; EBMYCG00000018957.
GeneID	4696432.
GenomeReviews	Gene locus BCG_0861 in contig AM408590_GR.
KEGG	mbb:BCG_0861.
PATRIC	18012320. VBIMycBov80988_0935.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1KGU2_MYCBP

Accession

Primary (citable) accession number: A1KGU2

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)