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A1KGQ5 (A1KGQ5_MYCBP) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138 EMBL CAL70810.1
Ordered Locus Names:BCG_0824
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP] EMBL CAL70810.1
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 312206ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding137 – 19357ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2821Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2841Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
A1KGQ5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 1FB82706EBEB19A1

FASTA42243,509
        10         20         30         40         50         60 
MRVLVIGSGA REHALLLALG KDPQVSGLIV APGNAGTARI AEQHDVDITS AEAVVALARE 

        70         80         90        100        110        120 
VGADMVVIGP EVPLVLGVAD AVRAAGIVCF GPGKDAARIE GSKAFAKDVM AAAGVRTANS 

       130        140        150        160        170        180 
EIVDSPAHLD AALDRFGPPA GDPAWVVKDD RLAAGKGVVV TADRDVARAH GAALLEAGHP 

       190        200        210        220        230        240 
VLLESYLDGP EVSLFCVVDR TVVVPLLPAQ DFKRVGEDDT GLNTGGMGAY APLPWLPDNI 

       250        260        270        280        290        300 
YREVVSRIVE PVAAELVRRG SSFCGLLYVG LAITARGPAV VEFNCRFGDP ETQAVLALLE 

       310        320        330        340        350        360 
SPLGQLLHAA ATGKLADFGE LRWRDGVAVT VVLAAENYPG RPRVGDVVVG SEAEGVLHAG 

       370        380        390        400        410        420 
TTRRDDGAIV SSGGRVLSVV GTGADLSAAR AHAYEILSSI RLPGGHFRSD IGLRAAEGKI 


SV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM408590 Genomic DNA. Translation: CAL70810.1.
RefSeqYP_976919.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KGQ5.
SMRA1KGQ5. Positions 1-415.
ModBaseSearch...

Protein-protein interaction databases

STRING410289.BCG_0824.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL70810; CAL70810; BCG_0824.
GeneID4697643.
KEGGmbb:BCG_0824.
PATRIC18012239. VBIMycBov80988_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-835-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1KGQ5_MYCBP
AccessionPrimary (citable) accession number: A1KGQ5
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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