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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferaseUniRule annotation (EC:2.1.1.144UniRule annotation)
Gene namesi
Name:tamUniRule annotation
Ordered Locus Names:BCG_0334
OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
Taxonomic identifieri410289 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001472 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Trans-aconitate 2-methyltransferasePRO_1000056561Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1KFB7.
SMRiA1KFB7. Positions 7-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. Tam family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A1KFB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWDPDVYLAF SGHRNRPFYE LVSRVGLERA RRVVDLGCGP GHLTRYLARR
60 70 80 90 100
WPGAVIEALD SSPEMVAAAA ERGIDATTGD LRDWKPKPDT DVVVSNAALH
110 120 130 140 150
WVPEHSDLLV RWVDELAPGS WIAVQIPGNF ETPSHAAVRA LARREPYAKL
160 170 180 190 200
MRDIPFRVGA VVQSPAYYAE LLMDTGCKVD VWETTYLHQL TGEHPVLDWI
210 220 230 240 250
TGSALVPVRE RLSDESWQQF RQELIPLLND AYPPRADGST IFPFRRLFMV
260
AEVGGARRSG G
Length:261
Mass (Da):29,268
Last modified:February 6, 2007 - v1
Checksum:iB92D46F1A5BA7A02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL70319.1.
RefSeqiWP_003401538.1. NC_008769.1.

Genome annotation databases

EnsemblBacteriaiCAL70319; CAL70319; BCG_0334.
KEGGimbb:BCG_0334.
PATRICi18011162. VBIMycBov80988_0361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA. Translation: CAL70319.1.
RefSeqiWP_003401538.1. NC_008769.1.

3D structure databases

ProteinModelPortaliA1KFB7.
SMRiA1KFB7. Positions 7-251.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL70319; CAL70319; BCG_0334.
KEGGimbb:BCG_0334.
PATRICi18011162. VBIMycBov80988_0361.

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiETTYLHV.

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-339-MONOMER.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAM_MYCBP
AccessioniPrimary (citable) accession number: A1KFB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.