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A1KF28

- TRMB_MYCBP

UniProt

A1KF28 - TRMB_MYCBP

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, BCG_0245c
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine By similarity
Binding sitei136 – 1361S-adenosyl-L-methionine By similarity
Active sitei159 – 1591 By similarity
Binding sitei159 – 1591S-adenosyl-L-methionine By similarity
Binding sitei163 – 1631Substrate By similarity
Binding sitei195 – 1951Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMBOV410289:GJW7-249-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:BCG_0245c
    OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
    Taxonomic identifieri410289 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001472: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288181Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410289.BCG_0245c.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KF28.
    SMRiA1KF28. Positions 47-235.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni232 – 2354Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiFATDWEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KF28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHHGQMHAQ PGVGLRPDTP VASGQLPSTS IRSRRSGISK AQRETWERLW    50
    PELGLLALPQ SPRGTPVDTR AWFGRDAPVV LEIGSGSGTS TLAMAKAEPH 100
    VDVIAVDVYR RGLAQLLCAI DKVGSDGINI RLILGNAVDV LQHLIAPDSL 150
    CGVRVFFPDP WPKARHHKRR LLQPATMALI ADRLVPSGVL HAATDHPGYA 200
    EHIAAAGDAE PRLVRVDPDT ELLPISVVRP ATKYERKAQL GGGAVIELLW 250
    KKHGCSERDL KIR 263
    Length:263
    Mass (Da):28,547
    Last modified:February 6, 2007 - v1
    Checksum:i5CECF14C9650AF07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL70229.1.
    RefSeqiYP_976343.1. NC_008769.1.

    Genome annotation databases

    EnsemblBacteriaiCAL70229; CAL70229; BCG_0245c.
    GeneIDi4697253.
    KEGGimbb:BCG_0245c.
    PATRICi18010978. VBIMycBov80988_0269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL70229.1 .
    RefSeqi YP_976343.1. NC_008769.1.

    3D structure databases

    ProteinModelPortali A1KF28.
    SMRi A1KF28. Positions 47-235.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 410289.BCG_0245c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL70229 ; CAL70229 ; BCG_0245c .
    GeneIDi 4697253.
    KEGGi mbb:BCG_0245c.
    PATRICi 18010978. VBIMycBov80988_0269.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi FATDWEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MBOV410289:GJW7-249-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCG / Pasteur 1173P2.

    Entry informationi

    Entry nameiTRMB_MYCBP
    AccessioniPrimary (citable) accession number: A1KF28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: June 11, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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