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A1KEK9

- SYL_MYCBP

UniProt

A1KEK9 - SYL_MYCBP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei742 – 7421ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBOV410289:GJW7-77-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BCG_0072
    OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
    Taxonomic identifieri410289 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001472: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 969969Leucine--tRNA ligasePRO_1000009373Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi410289.BCG_0072.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KEK9.
    SMRiA1KEK9. Positions 35-969.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi78 – 8912"HIGH" regionAdd
    BLAST
    Motifi739 – 7435"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KEK9-1 [UniParc]FASTAAdd to Basket

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    MTESPTAGPG GVPRADDADS DVPRYRYTAE LAARLERTWQ ENWARLGTFN    50
    VPNPVGSLAP PDGAAVPDDK LFVQDMFPYP SGEGLHVGHP LGYIATDVYA 100
    RYFRMVGRNV LHALGFDAFG LPAEQYAVQT GTHPRTRTEA NVVNFRRQLG 150
    RLGFGHDSRR SFSTTDVDFY RWTQWIFLQI YNAWFDTTAN KARPISELVA 200
    EFESGARCLD GGRDWAKLTA GERADVIDEY RLVYRADSLV NWCPGLGTVL 250
    ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYADRLLDD LDVLDWPEQV 300
    KTMQRNWIGR STGAVALFSA RAASDDGFEV DIEVFTTRPD TLFGATYLVL 350
    APEHDLVDEL VAASWPAGVN PLWTYGGGTP GEAIAAYRRA IAAKSDLERQ 400
    ESREKTGVFL GSYAINPANG EPVPIFIADY VLAGYGTGAI MAVPGHDQRD 450
    WDFARAFGLP IVEVIAGGNI SESAYTGDGI LVNSDYLNGM SVPAAKRAIV 500
    DRLESAGRGR ARIEFKLRDW LFARQRYWGE PFPIVYDSDG RPHALDEAAL 550
    PVELPDVPDY SPVLFDPDDA DSEPSPPLAK ATEWVHVDLD LGDGLKPYSR 600
    DTNVMPQWAG SSWYELRYTD PHNSERFCAK ENEAYWMGPR PAEHGPDDPG 650
    GVDLYVGGAE HAVLHLLYSR FWHKVLYDLG HVSSREPYRR LVNQGYIQAY 700
    AYTDARGSYV PAEQVIERGD RFVYPGPDGE VEVFQEFGKI GKSLKNSVSP 750
    DEICDAYGAD TLRVYEMSMG PLEASRPWAT KDVVGAYRFL QRVWRLVVDE 800
    HTGETRVADG VELDIDTLRA LHRTIVGVSE DFAALRNNTA TAKLIEYTNH 850
    LTKKHRDAVP RAAVEPLVQM LAPLAPHIAE ELWLRLGNTT SLAHGPFPKA 900
    DAAYLVDETV EYPVQVNGKV RGRVVVAADT DEETLKAAVL TDEKVQAFLA 950
    GATPRKVIVV AGRLVNLVI 969
    Length:969
    Mass (Da):107,595
    Last modified:February 6, 2007 - v1
    Checksum:iA07C835FC1B428D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL70056.1.
    RefSeqiYP_976174.1. NC_008769.1.

    Genome annotation databases

    EnsemblBacteriaiCAL70056; CAL70056; BCG_0072.
    GeneIDi4697737.
    KEGGimbb:BCG_0072.
    PATRICi18010599. VBIMycBov80988_0080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL70056.1 .
    RefSeqi YP_976174.1. NC_008769.1.

    3D structure databases

    ProteinModelPortali A1KEK9.
    SMRi A1KEK9. Positions 35-969.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410289.BCG_0072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL70056 ; CAL70056 ; BCG_0072 .
    GeneIDi 4697737.
    KEGGi mbb:BCG_0072.
    PATRICi 18010599. VBIMycBov80988_0080.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MBOV410289:GJW7-77-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCG / Pasteur 1173P2.

    Entry informationi

    Entry nameiSYL_MYCBP
    AccessioniPrimary (citable) accession number: A1KEK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3