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A1KBR9

- PYRF_AZOSB

UniProt

A1KBR9 - PYRF_AZOSB

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:azo3659
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_1000066454Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi62928.azo3659.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KBR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245747.
    KOiK01591.
    OMAiQSAINIR.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KBR9-1 [UniParc]FASTAAdd to Basket

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    MHFMTALRAA WQQRDSLLCV GLDPDPARFP AHLQGRPDAI FEFCAAIVDA    50
    TADLVCSFKP QIAYFAARRA EDQLEALIDH IHAHHPGVPV ILDAKRGDIG 100
    STAEQYAVEA FERFKADAIT VNPYMGRDSV DPYLAYPDKG VILLCRTSNP 150
    GGSDLQFLDV GGEKLYERVA RLVAEDWNAS GNCGLVVGAT FPAEIARVRA 200
    LTGEMPLLVP GIGAQGGDIE ATVKAGRTAA GGGLMINSSR AILYAGKGED 250
    FAAAARAAAL QTRDAINAYR 270
    Length:270
    Mass (Da):28,828
    Last modified:February 6, 2007 - v1
    Checksum:i47B6076A2BBD95F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL96275.1.
    RefSeqiWP_011767381.1. NC_008702.1.
    YP_935161.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL96275; CAL96275; azo3659.
    GeneIDi4610185.
    KEGGiazo:azo3659.
    PATRICi21015774. VBIAzoSp26047_3705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL96275.1 .
    RefSeqi WP_011767381.1. NC_008702.1.
    YP_935161.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1KBR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo3659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL96275 ; CAL96275 ; azo3659 .
    GeneIDi 4610185.
    KEGGi azo:azo3659.
    PATRICi 21015774. VBIAzoSp26047_3705.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245747.
    KOi K01591.
    OMAi QSAINIR.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiPYRF_AZOSB
    AccessioniPrimary (citable) accession number: A1KBR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3