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A1KBR9

- PYRF_AZOSB

UniProt

A1KBR9 - PYRF_AZOSB

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donorUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:azo3659
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylasePRO_1000066454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo3659.

Structurei

3D structure databases

ProteinModelPortaliA1KBR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiQSAINIR.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KBR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHFMTALRAA WQQRDSLLCV GLDPDPARFP AHLQGRPDAI FEFCAAIVDA
60 70 80 90 100
TADLVCSFKP QIAYFAARRA EDQLEALIDH IHAHHPGVPV ILDAKRGDIG
110 120 130 140 150
STAEQYAVEA FERFKADAIT VNPYMGRDSV DPYLAYPDKG VILLCRTSNP
160 170 180 190 200
GGSDLQFLDV GGEKLYERVA RLVAEDWNAS GNCGLVVGAT FPAEIARVRA
210 220 230 240 250
LTGEMPLLVP GIGAQGGDIE ATVKAGRTAA GGGLMINSSR AILYAGKGED
260 270
FAAAARAAAL QTRDAINAYR
Length:270
Mass (Da):28,828
Last modified:February 6, 2007 - v1
Checksum:i47B6076A2BBD95F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL96275.1.
RefSeqiWP_011767381.1. NC_008702.1.
YP_935161.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL96275; CAL96275; azo3659.
GeneIDi4610185.
KEGGiazo:azo3659.
PATRICi21015774. VBIAzoSp26047_3705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL96275.1 .
RefSeqi WP_011767381.1. NC_008702.1.
YP_935161.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1KBR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo3659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL96275 ; CAL96275 ; azo3659 .
GeneIDi 4610185.
KEGGi azo:azo3659.
PATRICi 21015774. VBIAzoSp26047_3705.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi QSAINIR.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiPYRF_AZOSB
AccessioniPrimary (citable) accession number: A1KBR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3