Reviewed, UniProtKB/Swiss-Prot A1KB72 (PYRB_AZOSB)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	azo3462

Organism

Azoarcus sp. (strain BH72) [Complete proteome] [HAMAP]

Taxonomic identifier

62928 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301553

Sequences

	Sequence		Length	Mass (Da)
	A1KB72-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8A732B7E397F97A2	FASTA	319	35,002
	10 20 30 40 50 60 MRNPQLNEHG ELQHLLTLDG LPRQIITAIL DTAAPFTEVA EREVKKLPLL RGKSVFNLFF 70 80 90 100 110 120 ENSTRTRTTF EIAAKRLSAD VVNLNIATSS SNKGESLLDT VDNLSAMQAD MFVVRHAASG 130 140 150 160 170 180 APFLIAQHLL ATGRDHIRVV NAGDGRHAHP TQGLLDMYTI RHYKGDFTNL VVAIVGDVLH 190 200 210 220 230 240 SRVARSQIAA LTTLGVPEVR VIGPKTLLPT EVERMGVRVF HDMREGLKDV DVVMMLRLQN 250 260 270 280 290 300 ERMNGALLPT PQEYYKIWGL TAEKLALAKP DAIVMHPGPM NRGVEIDSAV ADGTQAVILP 310 QVTFGIAVRM AVMSMLGSH

References

[1]

"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72." Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A. Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM406670 Genomic DNA. Translation: CAL96078.1.
RefSeq	YP_934964.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1KB72.
Genome annotation databases
GeneID	4609675.
GenomeReviews	Gene locus azo3462 in contig AM406670_GR.
KEGG	azo:azo3462.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CHANIIN.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_AZOSB

Accession

Primary (citable) accession number: A1KB72

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)