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A1KAV5

- HIS4_AZOSB

UniProt

A1KAV5 - HIS4_AZOSB

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene
hisA, azo3345
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Proton acceptor By similarity
Active sitei131 – 1311Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:azo3345
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2512511-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotationPRO_0000290449Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo3345.

Structurei

3D structure databases

ProteinModelPortaliA1KAV5.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
OMAiGWAEETD.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

Sequencei

Sequence statusi: Complete.

A1KAV5-1 [UniParc]FASTAAdd to Basket

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MLLIPAIDLK DGQCVRLKQG EMDDATVFSE DPAAMARHWI KQGARRLHLV    50
DLNGAFAGKP KNGGAIRAIT DEVGDDIPVQ LGGGIRDLDT IEHYLDNGIS 100
YVIIGTAAVK NPGFLHDACG AFPGHIIVGL DAKDGKVAVD GWSKMTGHDV 150
VDLAKKFEDY GVEAVIYTDI GRDGMLSGVN IEATVRLARA LRIPVIASGG 200
IASLTDIEAL CAVEDEGIMG AITGRAIYEG TLDLSAAQSR ADALRAPGGA 250
A 251
Length:251
Mass (Da):26,301
Last modified:February 6, 2007 - v1
Checksum:iF3CBE6488BA174A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95961.1.
RefSeqiWP_011767068.1. NC_008702.1.
YP_934847.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95961; CAL95961; azo3345.
GeneIDi4609005.
KEGGiazo:azo3345.
PATRICi21015136. VBIAzoSp26047_3390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95961.1 .
RefSeqi WP_011767068.1. NC_008702.1.
YP_934847.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1KAV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo3345.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL95961 ; CAL95961 ; azo3345 .
GeneIDi 4609005.
KEGGi azo:azo3345.
PATRICi 21015136. VBIAzoSp26047_3390.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
OMAi GWAEETD.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiHIS4_AZOSB
AccessioniPrimary (citable) accession number: A1KAV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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