Reviewed, UniProtKB/Swiss-Prot A1KAT2 (TRPC_AZOSB)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	azo3322

Organism

Azoarcus sp. (strain BH72) [Complete proteome] [HAMAP]

Taxonomic identifier

62928 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000018433

Sequences

	Sequence		Length	Mass (Da)
	A1KAT2-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 415802579514830F	FASTA	264	27,915
	10 20 30 40 50 60 MSDILQKICA VKREEVTAAL AAKPLAIVRA EAEAQPAARD FVGAIRGRIT AGRPAVIAEI 70 80 90 100 110 120 KKASPSKGVI REDFRPADIA PSYEAAGAAC LSVLTDKPFF QGAPEYLQAA RAACALPALR 130 140 150 160 170 180 KDFLVDAYQV YEARAMGADA ILLIAACLSL AEMQDMEAIA HGLGMGVLVE VHDGAELEQA 190 200 210 220 230 240 LKLRTPLVGI NNRNLRTFEV SLQTTLGLLP RLAAEADRIV VTESGILAPA DVALMRENGV 250 260 NAFLVGEAFM RVPDPGAGLR ALFG

References

[1]

"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72." Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A. Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM406670 Genomic DNA. Translation: CAL95938.1.
RefSeq	YP_934824.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1KAT2.
Genome annotation databases
GeneID	4607918.
GenomeReviews	Gene locus azo3322 in contig AM406670_GR.
KEGG	azo:azo3322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PLLCKDF.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_AZOSB

Accession

Primary (citable) accession number: A1KAT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)