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A1KAH8

- PROA_AZOSB

UniProt

A1KAH8 - PROA_AZOSB

Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

    Catalytic activityi

    L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00360.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
    Short name:
    GPRUniRule annotation
    Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
    Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
    Short name:
    GSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:proAUniRule annotation
    Ordered Locus Names:azo3218
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Gamma-glutamyl phosphate reductasePRO_0000340871Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi62928.azo3218.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KAH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0014.
    HOGENOMiHOG000246356.
    KOiK00147.
    OMAiLEGICHI.
    OrthoDBiEOG6FFSCX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPiMF_00412. ProA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000151. GPR. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00407. proA. 1 hit.
    PROSITEiPS01223. PROA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KAH8-1 [UniParc]FASTAAdd to Basket

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    MQTVGREARA ASRTLAAAST DAKNSALVAM AQAIRDSRDA LLAANAADLA    50
    EARAAGLDEA LIDRLTLSAK GVEGMAAGLE QVAALPDPVG EITDVKRRPS 100
    GIQVGKMRVP LGVVGIIYEA RPNVTADAAA LCLKSGNAAI LRGGKEALRS 150
    NQAIASCVRT GLAAAGLPQT AVQVLETTDR AAVGALITMP EFVDVIVPRG 200
    GKGLIERISS EARVPVIKHL DGNCHVYVDD HADPAKVLPI VENAKTQRYG 250
    TCNTTESLLV ARAVAPRFLS DIGRMLAARN VEMRACPEAL ALLREAGIEG 300
    ARLSPATEQD WHEEYLAPII AIRVVAGLDE AIAHINTYSS GHTEAILTEH 350
    YTHAMRFLRE VDSASVMVNA STRFADGFEY GLGAEIGIST DKIHARGPVG 400
    LEGLTSQKWI VFGNGEIRR 419
    Length:419
    Mass (Da):44,257
    Last modified:February 6, 2007 - v1
    Checksum:i28F270332CA1E276
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95834.1.
    RefSeqiWP_011766942.1. NC_008702.1.
    YP_934720.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL95834; CAL95834; azo3218.
    GeneIDi4609012.
    KEGGiazo:azo3218.
    PATRICi21014890. VBIAzoSp26047_3267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95834.1 .
    RefSeqi WP_011766942.1. NC_008702.1.
    YP_934720.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1KAH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo3218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL95834 ; CAL95834 ; azo3218 .
    GeneIDi 4609012.
    KEGGi azo:azo3218.
    PATRICi 21014890. VBIAzoSp26047_3267.

    Phylogenomic databases

    eggNOGi COG0014.
    HOGENOMi HOG000246356.
    KOi K00147.
    OMAi LEGICHI.
    OrthoDBi EOG6FFSCX.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00360 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 2 hits.
    HAMAPi MF_00412. ProA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR000965. G-glutamylP_reductase.
    IPR020593. G-glutamylP_reductase_CS.
    IPR012134. Glu-5-SA_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000151. GPR. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00407. proA. 1 hit.
    PROSITEi PS01223. PROA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiPROA_AZOSB
    AccessioniPrimary (citable) accession number: A1KAH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3