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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:azo3218
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Gamma-glutamyl phosphate reductasePRO_0000340871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo3218.

Structurei

3D structure databases

ProteinModelPortaliA1KAH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KAH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTVGREARA ASRTLAAAST DAKNSALVAM AQAIRDSRDA LLAANAADLA
60 70 80 90 100
EARAAGLDEA LIDRLTLSAK GVEGMAAGLE QVAALPDPVG EITDVKRRPS
110 120 130 140 150
GIQVGKMRVP LGVVGIIYEA RPNVTADAAA LCLKSGNAAI LRGGKEALRS
160 170 180 190 200
NQAIASCVRT GLAAAGLPQT AVQVLETTDR AAVGALITMP EFVDVIVPRG
210 220 230 240 250
GKGLIERISS EARVPVIKHL DGNCHVYVDD HADPAKVLPI VENAKTQRYG
260 270 280 290 300
TCNTTESLLV ARAVAPRFLS DIGRMLAARN VEMRACPEAL ALLREAGIEG
310 320 330 340 350
ARLSPATEQD WHEEYLAPII AIRVVAGLDE AIAHINTYSS GHTEAILTEH
360 370 380 390 400
YTHAMRFLRE VDSASVMVNA STRFADGFEY GLGAEIGIST DKIHARGPVG
410
LEGLTSQKWI VFGNGEIRR
Length:419
Mass (Da):44,257
Last modified:February 6, 2007 - v1
Checksum:i28F270332CA1E276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL95834.1.
RefSeqiWP_011766942.1. NC_008702.1.
YP_934720.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95834; CAL95834; azo3218.
KEGGiazo:azo3218.
PATRICi21014890. VBIAzoSp26047_3267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL95834.1.
RefSeqiWP_011766942.1. NC_008702.1.
YP_934720.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1KAH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo3218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL95834; CAL95834; azo3218.
KEGGiazo:azo3218.
PATRICi21014890. VBIAzoSp26047_3267.

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiCNAIETL.
OrthoDBiEOG6FFSCX.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00360.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
IPR000965. GPR_dom.
[Graphical view]
PfamiPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiPROA_AZOSB
AccessioniPrimary (citable) accession number: A1KAH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.