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A1KAH5

- SYL_AZOSB

UniProt

A1KAH5 - SYL_AZOSB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei631 – 6311ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:azo3215
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Leucine--tRNA ligasePRO_1000009290Add
    BLAST

    Proteomic databases

    PRIDEiA1KAH5.

    Interactioni

    Protein-protein interaction databases

    STRINGi62928.azo3215.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KAH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi628 – 6325"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KAH5-1 [UniParc]FASTAAdd to Basket

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    MQDKYQPAAV ETAAQQHWES TAAFRVTEDA TRPKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLARFHRMRG YNVLQPMGWD AFGMPAENAA IQNNVPPAKW 100
    TYANIDYMKG QLKRLGFAID WSREVATCTP EYYRWEQWLF TRLFEKGLIY 150
    KKLGTVNWDP VDETVLANEQ VIDGRGWRSG ALVEKREIPM YYMKITAYAD 200
    ELLEALDGLP GWPEQVKLMQ KNWIGRSEGV EVHFPYDLST IGSSGVLKVF 250
    TTRGDTLMGA TYVAVAAEHP LATQAAAGNP ELAAFIDECK QGGVAEADLA 300
    TMEKKGMPTG LRVVHPITGE YLPVWVANYV LMGYGEGAVM AVPAHDERDF 350
    AFATKYKLPI KMVVRSTHDA YENVAAPWID AYAEHGKLVN SGKYDNLHFQ 400
    DAVDAIAADL AAKGLGNKRV QYRLRDWGIS RQRYWGCPIP MVRCDDCGDV 450
    PVPDEQLPVV LPENVEITGR GSPLAKMPEF YQCSCPKCGK PARRETDTMD 500
    TFVESSWYFL RYASPDSTTA MVDERVNYWA PVDQYIGGIE HAILHLLYSR 550
    FFTRAMRDCG LVNVSEPFTN LLTQGMVVAE TYYRELDGGK KQWLNPADVQ 600
    VERDERGRIT AAKLASDGLP VVIGGTEKMS KSKNNGVDPQ ALVDQYGADT 650
    ARLFIIFAAP PDQQLEWSDS GVEGASRFLR RVWNFGHAFA SEFRAALPAA 700
    RALAAGTLPA ALADVRREIH THLKQANYDF GKHQFNTVVS AAMKILNALE 750
    KAPRDDAAAH AEVAEEGFSI LVRLLSPITP HIAHALWQDC GFGGDIVQAA 800
    WPEPLEAALK QDEIELMLQV NGKLRGSVKV AADAGKSDIE ALALASEAAQ 850
    KFMEGKPPKK VVVVPGRLVN IVV 873
    Length:873
    Mass (Da):96,943
    Last modified:February 6, 2007 - v1
    Checksum:i9516D7967993F4CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95831.1.
    RefSeqiWP_011766939.1. NC_008702.1.
    YP_934717.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL95831; CAL95831; azo3215.
    GeneIDi4607854.
    KEGGiazo:azo3215.
    PATRICi21014884. VBIAzoSp26047_3264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95831.1 .
    RefSeqi WP_011766939.1. NC_008702.1.
    YP_934717.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1KAH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo3215.

    Proteomic databases

    PRIDEi A1KAH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL95831 ; CAL95831 ; azo3215 .
    GeneIDi 4607854.
    KEGGi azo:azo3215.
    PATRICi 21014884. VBIAzoSp26047_3264.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiSYL_AZOSB
    AccessioniPrimary (citable) accession number: A1KAH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3