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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei631ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:azo3215
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000092901 – 873Leucine--tRNA ligaseAdd BLAST873

Proteomic databases

PRIDEiA1KAH5.

Interactioni

Protein-protein interaction databases

STRINGi62928.azo3215.

Structurei

3D structure databases

ProteinModelPortaliA1KAH5.
SMRiA1KAH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi628 – 632"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiTFMVLAP.
OrthoDBiPOG091H01JZ.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A1KAH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKYQPAAV ETAAQQHWES TAAFRVTEDA TRPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLARFHRMRG YNVLQPMGWD AFGMPAENAA IQNNVPPAKW
110 120 130 140 150
TYANIDYMKG QLKRLGFAID WSREVATCTP EYYRWEQWLF TRLFEKGLIY
160 170 180 190 200
KKLGTVNWDP VDETVLANEQ VIDGRGWRSG ALVEKREIPM YYMKITAYAD
210 220 230 240 250
ELLEALDGLP GWPEQVKLMQ KNWIGRSEGV EVHFPYDLST IGSSGVLKVF
260 270 280 290 300
TTRGDTLMGA TYVAVAAEHP LATQAAAGNP ELAAFIDECK QGGVAEADLA
310 320 330 340 350
TMEKKGMPTG LRVVHPITGE YLPVWVANYV LMGYGEGAVM AVPAHDERDF
360 370 380 390 400
AFATKYKLPI KMVVRSTHDA YENVAAPWID AYAEHGKLVN SGKYDNLHFQ
410 420 430 440 450
DAVDAIAADL AAKGLGNKRV QYRLRDWGIS RQRYWGCPIP MVRCDDCGDV
460 470 480 490 500
PVPDEQLPVV LPENVEITGR GSPLAKMPEF YQCSCPKCGK PARRETDTMD
510 520 530 540 550
TFVESSWYFL RYASPDSTTA MVDERVNYWA PVDQYIGGIE HAILHLLYSR
560 570 580 590 600
FFTRAMRDCG LVNVSEPFTN LLTQGMVVAE TYYRELDGGK KQWLNPADVQ
610 620 630 640 650
VERDERGRIT AAKLASDGLP VVIGGTEKMS KSKNNGVDPQ ALVDQYGADT
660 670 680 690 700
ARLFIIFAAP PDQQLEWSDS GVEGASRFLR RVWNFGHAFA SEFRAALPAA
710 720 730 740 750
RALAAGTLPA ALADVRREIH THLKQANYDF GKHQFNTVVS AAMKILNALE
760 770 780 790 800
KAPRDDAAAH AEVAEEGFSI LVRLLSPITP HIAHALWQDC GFGGDIVQAA
810 820 830 840 850
WPEPLEAALK QDEIELMLQV NGKLRGSVKV AADAGKSDIE ALALASEAAQ
860 870
KFMEGKPPKK VVVVPGRLVN IVV
Length:873
Mass (Da):96,943
Last modified:February 6, 2007 - v1
Checksum:i9516D7967993F4CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL95831.1.
RefSeqiWP_011766939.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95831; CAL95831; azo3215.
KEGGiazo:azo3215.

Similar proteinsi

Entry informationi

Entry nameiSYL_AZOSB
AccessioniPrimary (citable) accession number: A1KAH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families