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A1KA97

- PUR5_AZOSB

UniProt

A1KA97 - PUR5_AZOSB

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:azo3136
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192991Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi62928.azo3136.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KA97.
    SMRiA1KA97. Positions 10-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiNPQENDI.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1KA97-1 [UniParc]FASTAAdd to Basket

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    MSVSNSASPS SLSYRDAGVD IEAGDALVDR IKPFAKRTMR PEVLGGIGGF    50
    GALFELSKKF KEPVLVSGTD GVGTKLKLAF QLNKHDTVGQ DLVAMSVNDI 100
    LVQGAEPLFF LDYFACGKLD VDTAADVVKG IAHGCELAGC ALIGGETAEM 150
    PSMYPEGEYD LAGFAVGAVE KADIIDGSKI VPGDVVLGLA SSGAHSNGYS 200
    LVRKIIEVAK PDLDADFHGR TFRDVVMEPT RIYVKPLLAL MQAMPGVVKG 250
    MAHITGGGIT ENVPRILRDE LTARIDAASW TLPPLFQWLQ QAGNVDTQEM 300
    YRVFNCGIGM AVVVAADVAD AVAAQLTAAG ETVYRIGRID SRKDGEAQTI 350
    VA 352
    Length:352
    Mass (Da):37,206
    Last modified:February 6, 2007 - v1
    Checksum:i6C990EC755CBBAE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95753.1.
    RefSeqiWP_011766861.1. NC_008702.1.
    YP_934639.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL95753; CAL95753; azo3136.
    GeneIDi4607812.
    KEGGiazo:azo3136.
    PATRICi21014708. VBIAzoSp26047_3182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL95753.1 .
    RefSeqi WP_011766861.1. NC_008702.1.
    YP_934639.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1KA97.
    SMRi A1KA97. Positions 10-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo3136.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL95753 ; CAL95753 ; azo3136 .
    GeneIDi 4607812.
    KEGGi azo:azo3136.
    PATRICi 21014708. VBIAzoSp26047_3182.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi NPQENDI.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiPUR5_AZOSB
    AccessioniPrimary (citable) accession number: A1KA97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3