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A1KA97

- PUR5_AZOSB

UniProt

A1KA97 - PUR5_AZOSB

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:azo3136
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192991Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo3136.

Structurei

3D structure databases

ProteinModelPortaliA1KA97.
SMRiA1KA97. Positions 10-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A1KA97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVSNSASPS SLSYRDAGVD IEAGDALVDR IKPFAKRTMR PEVLGGIGGF
60 70 80 90 100
GALFELSKKF KEPVLVSGTD GVGTKLKLAF QLNKHDTVGQ DLVAMSVNDI
110 120 130 140 150
LVQGAEPLFF LDYFACGKLD VDTAADVVKG IAHGCELAGC ALIGGETAEM
160 170 180 190 200
PSMYPEGEYD LAGFAVGAVE KADIIDGSKI VPGDVVLGLA SSGAHSNGYS
210 220 230 240 250
LVRKIIEVAK PDLDADFHGR TFRDVVMEPT RIYVKPLLAL MQAMPGVVKG
260 270 280 290 300
MAHITGGGIT ENVPRILRDE LTARIDAASW TLPPLFQWLQ QAGNVDTQEM
310 320 330 340 350
YRVFNCGIGM AVVVAADVAD AVAAQLTAAG ETVYRIGRID SRKDGEAQTI

VA
Length:352
Mass (Da):37,206
Last modified:February 6, 2007 - v1
Checksum:i6C990EC755CBBAE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95753.1.
RefSeqiWP_011766861.1. NC_008702.1.
YP_934639.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95753; CAL95753; azo3136.
GeneIDi4607812.
KEGGiazo:azo3136.
PATRICi21014708. VBIAzoSp26047_3182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95753.1 .
RefSeqi WP_011766861.1. NC_008702.1.
YP_934639.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1KA97.
SMRi A1KA97. Positions 10-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo3136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL95753 ; CAL95753 ; azo3136 .
GeneIDi 4607812.
KEGGi azo:azo3136.
PATRICi 21014708. VBIAzoSp26047_3182.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiPUR5_AZOSB
AccessioniPrimary (citable) accession number: A1KA97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3