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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37Substrate1
Binding sitei115Substrate1
Binding sitei148Substrate1
Binding sitei199ATP1
Binding sitei321ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi347 – 350ATP4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:azo2839
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000579611 – 394Phosphoglycerate kinaseAdd BLAST394

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi62928.azo2839.

Structurei

3D structure databases

ProteinModelPortaliA1K9F0.
SMRiA1K9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate binding3
Regioni60 – 63Substrate binding4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDMIFDIG.
OrthoDBiPOG091H00YN.

Family and domain databases

Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVKKLTDLD VRGKKVFIRA DLNVPQDEAG NITEDTRIRA SIPSIQYCLD
60 70 80 90 100
NGAAVMVTSH LGRPTEGEVG PDDTLAPVAV RLGQLLHKPV KLIANWVEGG
110 120 130 140 150
FEVKPGEVVL LENCRCNKGE KKDNEELAKK MAALCDVYVN DAFGTAHRAE
160 170 180 190 200
ATTHGIARFA PVSCAGILMG AEIDALSKAL HQPARPLVAI VGGAKVSTKL
210 220 230 240 250
TILKTLADKV DQLIVGGGIA NTFLLAAGKR IGESLAEPEM VREAQQVMDI
260 270 280 290 300
MKSRGAEVPL PIDVVVADEV SALARANRIS VDEVGPHDRI LDFGPKTSAK
310 320 330 340 350
LADIIAHAGT IVWNGPVGVF EHAQFAGGTK MMASAIAHSE AFSIAGGGDT
360 370 380 390
LAAIAKFHIA DDVGYISTGG GAFLEFLEGK KLPAIAALEA RYEG
Length:394
Mass (Da):41,548
Last modified:February 6, 2007 - v1
Checksum:i35854A5292CEB804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL95455.1.
RefSeqiWP_011766565.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95455; CAL95455; azo2839.
KEGGiazo:azo2839.

Similar proteinsi

Entry informationi

Entry nameiPGK_AZOSB
AccessioniPrimary (citable) accession number: A1K9F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families