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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37S-adenosyl-L-methionineUniRule annotation1
Binding sitei56S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei77S-adenosyl-L-methionineUniRule annotation1
Binding sitei121S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:azo2589
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000138891 – 233Ubiquinone biosynthesis O-methyltransferaseAdd BLAST233

Interactioni

Protein-protein interaction databases

STRINGi62928.azo2589.

Structurei

3D structure databases

ProteinModelPortaliA1K8Q1.
SMRiA1K8Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiGTHDWEK.
OrthoDBiPOG091H064Z.

Family and domain databases

HAMAPiMF_00472. UbiG. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K8Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNADPAEV QKFSDLAHRW WDPASEFKPL HEINPLRLDW IDGHCGLAGK
60 70 80 90 100
KVLDVGCGGG LLSEGMAQRG AEVSGIDLSE KALGVARLHL YESGLQVDYQ
110 120 130 140 150
LTSAEAHAAT HPAQFDVVTC MEMLEHVPNP ESTVHACAQM AKPGGAVFFS
160 170 180 190 200
TLNRNFKAYL FAVVGAEYLL NLLPRGTHDY AKFIKPSELS RYCRNAGLEL
210 220 230
VSLSGMTYNP ITKVYALSRD TDVNYMVHAR KLG
Length:233
Mass (Da):25,564
Last modified:February 6, 2007 - v1
Checksum:i99D72123658CDBF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL95206.1.
RefSeqiWP_011766316.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95206; CAL95206; azo2589.
KEGGiazo:azo2589.

Similar proteinsi

Entry informationi

Entry nameiUBIG_AZOSB
AccessioniPrimary (citable) accession number: A1K8Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families