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A1K8P4 (HEMH_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:azo2582
OrganismAzoarcus sp. (strain BH72) [Complete proteome] [HAMAP]
Taxonomic identifier62928 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Ferrochelatase HAMAP MF_00323
PRO_1000079190

Sites

Metal binding2091Iron By similarity
Metal binding2901Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A1K8P4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: A355EC9812CC480E

FASTA36340,511
        10         20         30         40         50         60 
MARFWTEAPH RHGSTARTGI LLVNLGTPVA PTAAALRPYL QQFLSDPRVV EIPRAVWLPL 

        70         80         90        100        110        120 
LNGVILNTRP RKSAAKYASI WTDEGSPLAV HTRRQAELIA ARFASRDDVR VDWAMRYGAP 

       130        140        150        160        170        180 
AVADKLGALR AAGCTRILVV PMYPQYAAST TASVMDEVAR CLQHWRNLPE LRFVRSFHDD 

       190        200        210        220        230        240 
PGYIGALAAS VREHWTRHGQ PDRLLMSFHG LPRYTLERGD PYHCECHRTA RLLAESLGLA 

       250        260        270        280        290        300 
PERVIVSFQS RFGRTRWLEP YTQPTLEALA RDGVGRVDVM CPGFVADCLE TLEEIAMECR 

       310        320        330        340        350        360 
AAFLGAGGRE FHYIPCLNER PDWIDALERR VRSEAGNWLT ATPPTDAERE AARGRALALG 


AAE

« Hide

References

[1]"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72."
Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. expand/collapse author list , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.
Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BH72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406670 Genomic DNA. Translation: CAL95199.1.
RefSeqYP_934086.1. NC_008702.1.

3D structure databases

ProteinModelPortalA1K8P4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1K8P4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4609028.
GenomeReviewsGene locus azo2582 in contig AM406670_GR.
KEGGazo:azo2582.
PATRIC21013596. VBIAzoSp26047_2628.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMAIRPAKSA.
PhylomeDBA1K8P4.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycASP62928:AZO2582-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_AZOSB
AccessionPrimary (citable) accession number: A1K8P4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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