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A1K8P2

- NADK_AZOSB

UniProt

A1K8P2 - NADK_AZOSB

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Protein

NAD kinase

Gene

nadK

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptorUniRule annotation
Binding sitei159 – 1591NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei178 – 1781NADUniRule annotation
Binding sitei247 – 2471NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 752NADUniRule annotation
Nucleotide bindingi148 – 1492NADUniRule annotation
Nucleotide bindingi189 – 1946NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:azo2580
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294NAD kinasePRO_1000059864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo2580.

Structurei

3D structure databases

ProteinModelPortaliA1K8P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K8P2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAHFRSVAL IGKYQSADVA ESVFAIANHL RQRGLVVWIE QGTASSIGGA
60 70 80 90 100
ADFTVASYEE IGSRAELAVV IGGDGTMLNA ARRLAEHQVP LVGVNLGRLG
110 120 130 140 150
FLTDVARSDA LQRLEEIVDG RYSEESRFML DAEVLRSGER VFQTLALNDV
160 170 180 190 200
VVNKGDLGRM IEFDLSIDGE FVYTQRSDGM IISTPTGSTA YALSANGPIL
210 220 230 240 250
HPGVGGIALV PLCPHALTAR PVTLPDTCRI EIRLLPPHDA SIHFDGQARF
260 270 280 290
DARAGDCVRL GRSPLAVRLL HPEGYNYYAM LREKLHWSAV PRHN
Length:294
Mass (Da):31,956
Last modified:February 6, 2007 - v1
Checksum:i18113FFCE947F9BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95197.1.
RefSeqiWP_011766307.1. NC_008702.1.
YP_934084.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL95197; CAL95197; azo2580.
GeneIDi4609708.
KEGGiazo:azo2580.
PATRICi21013592. VBIAzoSp26047_2626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL95197.1 .
RefSeqi WP_011766307.1. NC_008702.1.
YP_934084.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K8P2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo2580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL95197 ; CAL95197 ; azo2580 .
GeneIDi 4609708.
KEGGi azo:azo2580.
PATRICi 21013592. VBIAzoSp26047_2626.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiNADK_AZOSB
AccessioniPrimary (citable) accession number: A1K8P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3