A1K7J9 (OTC_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	azo2187

Organism

Azoarcus sp. (strain BH72) [Complete proteome] [HAMAP]

Taxonomic identifier

62928 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000084834
Regions
	Region	54 – 58	5	Carbamoyl phosphate binding By similarity
	Region	260 – 263	4	Ornithine binding By similarity
Sites
	Binding site	105	1	Carbamoyl phosphate By similarity
	Binding site	132	1	Carbamoyl phosphate By similarity
	Site	29	1	Important for structural integrity By similarity
	Site	145	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1K7J9 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 202E73D3A0897546	FASTA	311	35,240
	10 20 30 40 50 60 MSSPRHYLQF SDFTAAEYDH VFQRTRWIKE KFKQYEPYHP LFDRTLVMIF EKASTRTRLS 70 80 90 100 110 120 FEAGMQQLGG SAIYLNTRDS QLGRGEPVED AAQVISRMSD LVMIRTFEQD IIERFAAYSR 130 140 150 160 170 180 VPVINGLTNE YHPCQILADI YTFIEHRGSI KGKTVAWVGD SNNMCNTWLQ AAEVLDFKVR 190 200 210 220 230 240 VSTPPGYEVE PTDAGLRGTA HFAQFSDPLE ACRGADLVTT DVWTSMGFEA ENEARMKAFA 250 260 270 280 290 300 DWCVDAEMMS VAAPDALFMH CLPAHRGEEV TAEVIDGPQS VVWDEAENRL HVQKALMEYL 310 VLGRVGDEES N

References

[1]

"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72." Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A. Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BH72.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM406670 Genomic DNA. Translation: CAL94804.1.
RefSeq	YP_933691.1. NC_008702.1.
3D structure databases
ProteinModelPortal	A1K7J9.
ModBase	Search...
Protein-protein interaction databases
STRING	A1K7J9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4608336.
GenomeReviews	Gene locus azo2187 in contig AM406670_GR.
KEGG	azo:azo2187.
PATRIC	21012782. VBIAzoSp26047_2222.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GVDCVVT.
PhylomeDB	A1K7J9.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	ASP62928:AZO2187-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_AZOSB

Accession

Primary (citable) accession number: A1K7J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program