SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1K710

- A1K710_AZOSB

UniProt

A1K710 - A1K710_AZOSB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable 6-oxopurine nucleoside phosphorylase
Gene
azo1998
Organism
Azoarcus sp. (strain BH72)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage By similarity.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Phosphate By similarityUniRule annotation
Sitei165 – 1651Important for substrate specificity By similarityUniRule annotation
Binding sitei183 – 1831Substrate; via amide nitrogen By similarityUniRule annotation
Binding sitei184 – 1841Phosphate By similarityUniRule annotation
Sitei221 – 2211Important for substrate specificity By similarityUniRule annotation

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: InterPro
  2. phosphorylase activity Source: InterPro
  3. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine salvageUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-oxopurine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Purine nucleoside phosphorylase
Gene namesi
Ordered Locus Names:azo1998Imported
OrganismiAzoarcus sp. (strain BH72)Imported
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo1998.

Structurei

3D structure databases

ProteinModelPortaliA1K710.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Phosphate binding By similarityUniRule annotation
Regioni207 – 2093Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228987.
KOiK00772.
OMAiYRANISA.
OrthoDBiEOG6KHFXC.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K710-1 [UniParc]FASTAAdd to Basket

« Hide

MLAIIGGSGL TQLSTLEVVR REVCRTPYGE PSGALTFGTL AGKPVVFLAR    50
HGYGHTIPPH LVNYRANIWA LHQARATAVV SVASVGGIRA DFAPGTLAVP 100
DQIIDYTWGR KNTFFDGGEA PVRHIDFTHP YDEKLRRSLL AAATDAGEPI 150
FDGGVYASMQ GPRLETAAEI NRLERDGADL VGMTGMPEAA LARELDLPYA 200
ALNVVVNYAA GRSSSEHGIH FDSIELVLQE AMLRVRRVLE ALCRAG 246
Length:246
Mass (Da):26,490
Last modified:February 6, 2007 - v1
Checksum:i1868A9D5B1A59760
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94615.1.
RefSeqiWP_011765729.1. NC_008702.1.
YP_933502.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94615; CAL94615; azo1998.
GeneIDi4608374.
KEGGiazo:azo1998.
PATRICi21012394. VBIAzoSp26047_2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94615.1 .
RefSeqi WP_011765729.1. NC_008702.1.
YP_933502.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94615 ; CAL94615 ; azo1998 .
GeneIDi 4608374.
KEGGi azo:azo1998.
PATRICi 21012394. VBIAzoSp26047_2034.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228987.
KOi K00772.
OMAi YRANISA.
OrthoDBi EOG6KHFXC.

Enzyme and pathway databases

UniPathwayi UPA00606 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72Imported.

Entry informationi

Entry nameiA1K710_AZOSB
AccessioniPrimary (citable) accession number: A1K710
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi