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A1K710

- A1K710_AZOSB

UniProt

A1K710 - A1K710_AZOSB

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Protein

Probable 6-oxopurine nucleoside phosphorylase

Gene

azo1998

Organism
Azoarcus sp. (strain BH72)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81PhosphateUniRule annotation
Sitei165 – 1651Important for substrate specificityUniRule annotation
Binding sitei183 – 1831Substrate; via amide nitrogenUniRule annotation
Binding sitei184 – 1841PhosphateUniRule annotation
Sitei221 – 2211Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. purine-nucleoside phosphorylase activity Source: UniProtKB-EC
  3. S-methyl-5-thioadenosine phosphorylase activity Source: InterPro

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine salvageUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-oxopurine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Purine nucleoside phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:azo1998Imported
OrganismiAzoarcus sp. (strain BH72)Imported
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo1998.

Structurei

3D structure databases

ProteinModelPortaliA1K710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Phosphate bindingUniRule annotation
Regioni207 – 2093Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228987.
KOiK00772.
OMAiYRANISA.
OrthoDBiEOG6KHFXC.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K710-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAIIGGSGL TQLSTLEVVR REVCRTPYGE PSGALTFGTL AGKPVVFLAR
60 70 80 90 100
HGYGHTIPPH LVNYRANIWA LHQARATAVV SVASVGGIRA DFAPGTLAVP
110 120 130 140 150
DQIIDYTWGR KNTFFDGGEA PVRHIDFTHP YDEKLRRSLL AAATDAGEPI
160 170 180 190 200
FDGGVYASMQ GPRLETAAEI NRLERDGADL VGMTGMPEAA LARELDLPYA
210 220 230 240
ALNVVVNYAA GRSSSEHGIH FDSIELVLQE AMLRVRRVLE ALCRAG
Length:246
Mass (Da):26,490
Last modified:February 6, 2007 - v1
Checksum:i1868A9D5B1A59760
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94615.1.
RefSeqiWP_011765729.1. NC_008702.1.
YP_933502.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94615; CAL94615; azo1998.
GeneIDi4608374.
KEGGiazo:azo1998.
PATRICi21012394. VBIAzoSp26047_2034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94615.1 .
RefSeqi WP_011765729.1. NC_008702.1.
YP_933502.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94615 ; CAL94615 ; azo1998 .
GeneIDi 4608374.
KEGGi azo:azo1998.
PATRICi 21012394. VBIAzoSp26047_2034.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228987.
KOi K00772.
OMAi YRANISA.
OrthoDBi EOG6KHFXC.

Enzyme and pathway databases

UniPathwayi UPA00606 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72Imported.

Entry informationi

Entry nameiA1K710_AZOSB
AccessioniPrimary (citable) accession number: A1K710
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3