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A1K710

- A1K710_AZOSB

UniProt

A1K710 - A1K710_AZOSB

Protein

Probable 6-oxopurine nucleoside phosphorylase

Gene

azo1998

Organism
Azoarcus sp. (strain BH72)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.UniRule annotation

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81PhosphateUniRule annotation
    Sitei165 – 1651Important for substrate specificityUniRule annotation
    Binding sitei183 – 1831Substrate; via amide nitrogenUniRule annotation
    Binding sitei184 – 1841PhosphateUniRule annotation
    Sitei221 – 2211Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. purine-nucleoside phosphorylase activity Source: UniProtKB-EC
    3. S-methyl-5-thioadenosine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. purine ribonucleoside salvage Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Purine salvageUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 6-oxopurine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
    Alternative name(s):
    Purine nucleoside phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:azo1998Imported
    OrganismiAzoarcus sp. (strain BH72)Imported
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi62928.azo1998.

    Structurei

    3D structure databases

    ProteinModelPortaliA1K710.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Phosphate bindingUniRule annotation
    Regioni207 – 2093Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiYRANISA.
    OrthoDBiEOG6KHFXC.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1K710-1 [UniParc]FASTAAdd to Basket

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    MLAIIGGSGL TQLSTLEVVR REVCRTPYGE PSGALTFGTL AGKPVVFLAR    50
    HGYGHTIPPH LVNYRANIWA LHQARATAVV SVASVGGIRA DFAPGTLAVP 100
    DQIIDYTWGR KNTFFDGGEA PVRHIDFTHP YDEKLRRSLL AAATDAGEPI 150
    FDGGVYASMQ GPRLETAAEI NRLERDGADL VGMTGMPEAA LARELDLPYA 200
    ALNVVVNYAA GRSSSEHGIH FDSIELVLQE AMLRVRRVLE ALCRAG 246
    Length:246
    Mass (Da):26,490
    Last modified:February 6, 2007 - v1
    Checksum:i1868A9D5B1A59760
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94615.1.
    RefSeqiWP_011765729.1. NC_008702.1.
    YP_933502.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL94615; CAL94615; azo1998.
    GeneIDi4608374.
    KEGGiazo:azo1998.
    PATRICi21012394. VBIAzoSp26047_2034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94615.1 .
    RefSeqi WP_011765729.1. NC_008702.1.
    YP_933502.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1K710.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo1998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL94615 ; CAL94615 ; azo1998 .
    GeneIDi 4608374.
    KEGGi azo:azo1998.
    PATRICi 21012394. VBIAzoSp26047_2034.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi YRANISA.
    OrthoDBi EOG6KHFXC.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72Imported.

    Entry informationi

    Entry nameiA1K710_AZOSB
    AccessioniPrimary (citable) accession number: A1K710
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3