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A1K6Y5

- ACDH2_AZOSB

UniProt

A1K6Y5 - ACDH2_AZOSB

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Protein

Acetaldehyde dehydrogenase 2/3

Gene

mhpF

more
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
Binding sitei272 – 2721NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2/3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2/3UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:azo1973
AND
Name:nahO
Ordered Locus Names:azo2432
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Acetaldehyde dehydrogenase 2/3PRO_0000387618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo2432.

Structurei

3D structure databases

ProteinModelPortaliA1K6Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K6Y5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIKCALIG PGNIGTDLLY KLKRSPVLEP VWMVGIDAAS EGLARARELG
60 70 80 90 100
LKTTADGVDG LLPHVKADGV QIAFDATSAY VHAENSRKLN ELGVLMIDLT
110 120 130 140 150
PAAIGPFCVP PVNLKDHVGR GEMNVNMVTC GGQATIPMVA AVSRVQPVKY
160 170 180 190 200
GEIVATVSSK SAGPGTRKNI DEFTRTTAGA VEKVGGAKVG KAIIILNPAE
210 220 230 240 250
PPLIMRDTVH CLTETEPDQQ KITESIHAMI REVQKYVPGY KLVNGPVFDG
260 270 280 290 300
NRVSIYLEVE GLGDYLPKYA GNLDIMTAAG ARTAEMFAEE ILAGRLTLES

NRAVLA
Length:306
Mass (Da):32,572
Last modified:February 6, 2007 - v1
Checksum:iCC8ED08B6AB51E4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94590.1.
AM406670 Genomic DNA. Translation: CAL95049.1.
RefSeqiWP_011765706.1. NC_008702.1.
YP_933477.1. NC_008702.1.
YP_933936.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94590; CAL94590; azo1973.
CAL95049; CAL95049; azo2432.
GeneIDi4609221.
4609322.
KEGGiazo:azo1973.
azo:azo2432.
PATRICi21012338. VBIAzoSp26047_2006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94590.1 .
AM406670 Genomic DNA. Translation: CAL95049.1 .
RefSeqi WP_011765706.1. NC_008702.1.
YP_933477.1. NC_008702.1.
YP_933936.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K6Y5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo2432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94590 ; CAL94590 ; azo1973 .
CAL95049 ; CAL95049 ; azo2432 .
GeneIDi 4609221.
4609322.
KEGGi azo:azo1973.
azo:azo2432.
PATRICi 21012338. VBIAzoSp26047_2006.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiACDH2_AZOSB
AccessioniPrimary (citable) accession number: A1K6Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3