Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1K6Y5 (ACDH2_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2/3

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2/3
Gene names
Name:mhpF
Ordered Locus Names:azo1973
AND
Name:nahO
Ordered Locus Names:azo2432
OrganismAzoarcus sp. (strain BH72) [Complete proteome] [HAMAP]
Taxonomic identifier62928 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Acetaldehyde dehydrogenase 2/3 HAMAP-Rule MF_01657
PRO_0000387618

Regions

Nucleotide binding161 – 1699NAD By similarity

Sites

Active site1301Acyl-thioester intermediate By similarity
Binding site2721NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A1K6Y5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: CC8ED08B6AB51E4F

FASTA30632,572
        10         20         30         40         50         60 
MNKIKCALIG PGNIGTDLLY KLKRSPVLEP VWMVGIDAAS EGLARARELG LKTTADGVDG 

        70         80         90        100        110        120 
LLPHVKADGV QIAFDATSAY VHAENSRKLN ELGVLMIDLT PAAIGPFCVP PVNLKDHVGR 

       130        140        150        160        170        180 
GEMNVNMVTC GGQATIPMVA AVSRVQPVKY GEIVATVSSK SAGPGTRKNI DEFTRTTAGA 

       190        200        210        220        230        240 
VEKVGGAKVG KAIIILNPAE PPLIMRDTVH CLTETEPDQQ KITESIHAMI REVQKYVPGY 

       250        260        270        280        290        300 
KLVNGPVFDG NRVSIYLEVE GLGDYLPKYA GNLDIMTAAG ARTAEMFAEE ILAGRLTLES 


NRAVLA 

« Hide

References

[1]"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72."
Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. expand/collapse author list , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.
Nat. Biotechnol. 24:1385-1391(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BH72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM406670 Genomic DNA. Translation: CAL94590.1.
AM406670 Genomic DNA. Translation: CAL95049.1.
RefSeqYP_933477.1. NC_008702.1.
YP_933936.1. NC_008702.1.

3D structure databases

ProteinModelPortalA1K6Y5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING62928.azo2432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL94590; CAL94590; azo1973.
CAL95049; CAL95049; azo2432.
GeneID4609221.
4609322.
KEGGazo:azo1973.
azo:azo2432.
PATRIC21012338. VBIAzoSp26047_2006.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAREVQKYV.
OrthoDBEOG6H1PXH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_AZOSB
AccessionPrimary (citable) accession number: A1K6Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families