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Protein

Acetaldehyde dehydrogenase 2/3

Gene

mhpF

more
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
Binding sitei272 – 2721NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2/3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2/3UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:azo1973
AND
Name:nahO
Ordered Locus Names:azo2432
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Acetaldehyde dehydrogenase 2/3PRO_0000387618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo2432.

Structurei

3D structure databases

ProteinModelPortaliA1K6Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiQGNVNMV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K6Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIKCALIG PGNIGTDLLY KLKRSPVLEP VWMVGIDAAS EGLARARELG
60 70 80 90 100
LKTTADGVDG LLPHVKADGV QIAFDATSAY VHAENSRKLN ELGVLMIDLT
110 120 130 140 150
PAAIGPFCVP PVNLKDHVGR GEMNVNMVTC GGQATIPMVA AVSRVQPVKY
160 170 180 190 200
GEIVATVSSK SAGPGTRKNI DEFTRTTAGA VEKVGGAKVG KAIIILNPAE
210 220 230 240 250
PPLIMRDTVH CLTETEPDQQ KITESIHAMI REVQKYVPGY KLVNGPVFDG
260 270 280 290 300
NRVSIYLEVE GLGDYLPKYA GNLDIMTAAG ARTAEMFAEE ILAGRLTLES

NRAVLA
Length:306
Mass (Da):32,572
Last modified:February 6, 2007 - v1
Checksum:iCC8ED08B6AB51E4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94590.1.
AM406670 Genomic DNA. Translation: CAL95049.1.
RefSeqiWP_011765706.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94590; CAL94590; azo1973.
CAL95049; CAL95049; azo2432.
KEGGiazo:azo1973.
azo:azo2432.
PATRICi21012338. VBIAzoSp26047_2006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94590.1.
AM406670 Genomic DNA. Translation: CAL95049.1.
RefSeqiWP_011765706.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1K6Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo2432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL94590; CAL94590; azo1973.
CAL95049; CAL95049; azo2432.
KEGGiazo:azo1973.
azo:azo2432.
PATRICi21012338. VBIAzoSp26047_2006.

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiQGNVNMV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiACDH2_AZOSB
AccessioniPrimary (citable) accession number: A1K6Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.