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A1K6Y5

- ACDH2_AZOSB

UniProt

A1K6Y5 - ACDH2_AZOSB

Protein

Acetaldehyde dehydrogenase 2/3

Gene

mhpF

more
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301Acyl-thioester intermediateUniRule annotation
    Binding sitei272 – 2721NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 1699NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2/3UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2/3UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:azo1973
    AND
    Name:nahO
    Ordered Locus Names:azo2432
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Acetaldehyde dehydrogenase 2/3PRO_0000387618Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi62928.azo2432.

    Structurei

    3D structure databases

    ProteinModelPortaliA1K6Y5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiREVQKYV.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1K6Y5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKIKCALIG PGNIGTDLLY KLKRSPVLEP VWMVGIDAAS EGLARARELG    50
    LKTTADGVDG LLPHVKADGV QIAFDATSAY VHAENSRKLN ELGVLMIDLT 100
    PAAIGPFCVP PVNLKDHVGR GEMNVNMVTC GGQATIPMVA AVSRVQPVKY 150
    GEIVATVSSK SAGPGTRKNI DEFTRTTAGA VEKVGGAKVG KAIIILNPAE 200
    PPLIMRDTVH CLTETEPDQQ KITESIHAMI REVQKYVPGY KLVNGPVFDG 250
    NRVSIYLEVE GLGDYLPKYA GNLDIMTAAG ARTAEMFAEE ILAGRLTLES 300
    NRAVLA 306
    Length:306
    Mass (Da):32,572
    Last modified:February 6, 2007 - v1
    Checksum:iCC8ED08B6AB51E4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94590.1.
    AM406670 Genomic DNA. Translation: CAL95049.1.
    RefSeqiWP_011765706.1. NC_008702.1.
    YP_933477.1. NC_008702.1.
    YP_933936.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL94590; CAL94590; azo1973.
    CAL95049; CAL95049; azo2432.
    GeneIDi4609221.
    4609322.
    KEGGiazo:azo1973.
    azo:azo2432.
    PATRICi21012338. VBIAzoSp26047_2006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94590.1 .
    AM406670 Genomic DNA. Translation: CAL95049.1 .
    RefSeqi WP_011765706.1. NC_008702.1.
    YP_933477.1. NC_008702.1.
    YP_933936.1. NC_008702.1.

    3D structure databases

    ProteinModelPortali A1K6Y5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo2432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL94590 ; CAL94590 ; azo1973 .
    CAL95049 ; CAL95049 ; azo2432 .
    GeneIDi 4609221.
    4609322.
    KEGGi azo:azo1973.
    azo:azo2432.
    PATRICi 21012338. VBIAzoSp26047_2006.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi REVQKYV.
    OrthoDBi EOG6H1PXH.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiACDH2_AZOSB
    AccessioniPrimary (citable) accession number: A1K6Y5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3