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A1K6Q8

- LPXB_AZOSB

UniProt

A1K6Q8 - LPXB_AZOSB

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, azo1896
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:azo1896
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo1896.

Structurei

3D structure databases

ProteinModelPortaliA1K6Q8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K6Q8-1 [UniParc]FASTAAdd to Basket

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MAPRIAMVAG EASGDLLASH LIRAIRARVP DAEFFGIGGP KMQAEGFDAR    50
WPCELLAVHG YVDALKRYRE LSGIRKKLLK QVRRERPDAF IGVDAPDFNL 100
WLEGKIKAAG IPAIHFVSPS IWAWRGGRIK RIARSVTRML CMFPFEPELY 150
ERAGVPVSYV GHPLADVFPL EPDRAAARER LDIAPERKVV ALLPGSRQSE 200
VRNLGELFIE TAAMLAQRHP DVLFLVPLAT RETRELFSAA LARNKGDELP 250
LRMLFGHAVD AMTAADAVLV ASGTASLEAA LLKRPMVITY RMGKWQYRLM 300
KRMAYLPWIG LPNILCREGL VPELVQDDAT PPKLADALER WLVDPAACAA 350
LTERFTALHH SLRQNTAEKA AAAVLPYLSS SASCQPVSVS A 391
Length:391
Mass (Da):43,154
Last modified:February 6, 2007 - v1
Checksum:iF2B166A1679766F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94513.1.
RefSeqiWP_011765629.1. NC_008702.1.
YP_933400.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94513; CAL94513; azo1896.
GeneIDi4609754.
KEGGiazo:azo1896.
PATRICi21012180. VBIAzoSp26047_1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94513.1 .
RefSeqi WP_011765629.1. NC_008702.1.
YP_933400.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K6Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1896.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94513 ; CAL94513 ; azo1896 .
GeneIDi 4609754.
KEGGi azo:azo1896.
PATRICi 21012180. VBIAzoSp26047_1927.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiLPXB_AZOSB
AccessioniPrimary (citable) accession number: A1K6Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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