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A1K6Q8

- LPXB_AZOSB

UniProt

A1K6Q8 - LPXB_AZOSB

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:azo1896
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Lipid-A-disaccharide synthasePRO_1000049384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo1896.

Structurei

3D structure databases

ProteinModelPortaliA1K6Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K6Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRIAMVAG EASGDLLASH LIRAIRARVP DAEFFGIGGP KMQAEGFDAR
60 70 80 90 100
WPCELLAVHG YVDALKRYRE LSGIRKKLLK QVRRERPDAF IGVDAPDFNL
110 120 130 140 150
WLEGKIKAAG IPAIHFVSPS IWAWRGGRIK RIARSVTRML CMFPFEPELY
160 170 180 190 200
ERAGVPVSYV GHPLADVFPL EPDRAAARER LDIAPERKVV ALLPGSRQSE
210 220 230 240 250
VRNLGELFIE TAAMLAQRHP DVLFLVPLAT RETRELFSAA LARNKGDELP
260 270 280 290 300
LRMLFGHAVD AMTAADAVLV ASGTASLEAA LLKRPMVITY RMGKWQYRLM
310 320 330 340 350
KRMAYLPWIG LPNILCREGL VPELVQDDAT PPKLADALER WLVDPAACAA
360 370 380 390
LTERFTALHH SLRQNTAEKA AAAVLPYLSS SASCQPVSVS A
Length:391
Mass (Da):43,154
Last modified:February 6, 2007 - v1
Checksum:iF2B166A1679766F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94513.1.
RefSeqiWP_011765629.1. NC_008702.1.
YP_933400.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94513; CAL94513; azo1896.
GeneIDi4609754.
KEGGiazo:azo1896.
PATRICi21012180. VBIAzoSp26047_1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL94513.1 .
RefSeqi WP_011765629.1. NC_008702.1.
YP_933400.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K6Q8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1896.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94513 ; CAL94513 ; azo1896 .
GeneIDi 4609754.
KEGGi azo:azo1896.
PATRICi 21012180. VBIAzoSp26047_1927.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiLPXB_AZOSB
AccessioniPrimary (citable) accession number: A1K6Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3