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Protein

Malate dehydrogenase

Gene

mdh

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei106NADUniRule annotation1
Binding sitei113NADUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei166SubstrateUniRule annotation1
Active sitei191Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 18NADUniRule annotation7
Nucleotide bindingi130 – 132NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:azo1547
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943741 – 330Malate dehydrogenaseAdd BLAST330

Interactioni

Protein-protein interaction databases

STRINGi62928.azo1547.

Structurei

3D structure databases

ProteinModelPortaliA1K5Q9.
SMRiA1K5Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000220953.
KOiK00024.
OMAiRPRTKGM.
OrthoDBiPOG091H03R4.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K5Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAPVRVAV TGAAGQIGYS LLFRIASGEM LGKDQPVILQ LLDLPQAQKA
60 70 80 90 100
VKGVMMELED CAFPLLAGMI ATDDPNVAFK DAKVALLVGA RPRGPGMERK
110 120 130 140 150
DLLTENAKIF TVQGAAIGQY ADPDCKVLVV GNPCNTNAYI AKEVAQKYGR
160 170 180 190 200
VPAKNFTGML RLDHNRALSQ LAGKSGREVS SLKNLVVWGN HSPTMYADYR
210 220 230 240 250
FVKSNGDSVK DLINDAAWNK DVFLPTVGKR GAAIIEARGL SSAASAANAA
260 270 280 290 300
IDHIRDWVLG SNGEWVTMGI PSDGSYGIPE GVIYGFPVTT ENGEYKIVQG
310 320 330
LEIDEFSRER MTVTLNELLE EREGVKDLLA
Length:330
Mass (Da):35,527
Last modified:February 6, 2007 - v1
Checksum:iDEC4AA51D738E299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94164.1.
RefSeqiWP_011765280.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94164; CAL94164; azo1547.
KEGGiazo:azo1547.

Similar proteinsi

Entry informationi

Entry nameiMDH_AZOSB
AccessioniPrimary (citable) accession number: A1K5Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families