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A1K5C1

- NUON_AZOSB

UniProt

A1K5C1 - NUON_AZOSB

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:azo1409
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei74 – 9421HelicalUniRule annotationAdd
BLAST
Transmembranei106 – 12621HelicalUniRule annotationAdd
BLAST
Transmembranei128 – 14821HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 18321HelicalUniRule annotationAdd
BLAST
Transmembranei206 – 22621HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei272 – 29221HelicalUniRule annotationAdd
BLAST
Transmembranei301 – 32121HelicalUniRule annotationAdd
BLAST
Transmembranei336 – 35621HelicalUniRule annotationAdd
BLAST
Transmembranei379 – 39921HelicalUniRule annotationAdd
BLAST
Transmembranei410 – 43021HelicalUniRule annotationAdd
BLAST
Transmembranei465 – 48521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491NADH-quinone oxidoreductase subunit NPRO_0000391101Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo1409.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000100795.
KOiK00343.
OMAiMVSSNHL.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K5C1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFVVPDFYP ATAEIFVAVM ALVIMLATTF ARSVARGLAY GLTLVTLIGA
60 70 80 90 100
AIITYNTANP RAVTTFSNMF IGDLLGDVLK LLIYFSMAVA LLYGRSYLAD
110 120 130 140 150
RKLDKPEYYV LALLMTLGMM VMVTSNHLLS MYIGLELMSL SLYALVAFDR
160 170 180 190 200
DSARGTEAAM KYFVLGALAS GLLLYGMSML YGATGTLEIS GIAKSVYNQA
210 220 230 240 250
ANDTVLLFGL VFLMAGICFK LGVVPFHMWI PDVYHGANTA VTLIIATAPK
260 270 280 290 300
LAAFAMAVRL LVWGLFDVAE HWQTMLMFVA VLSIVLGNLA AIAQTNLKRM
310 320 330 340 350
LAYSGISHMG FMLLGLLSGV VDGDPHYALD AYSAAMFYAI SYVIMSLASF
360 370 380 390 400
GMIILLSRAG FEAENIDDFK GLNKRSPWFA AMMMFVMFSM AGIPFFIGFF
410 420 430 440 450
AKLAVLQAVV AAGYIWVAVV AVLMSVIGAF YYLRLVKVMY FDEPADATPI
460 470 480 490
QAPAELRVFL SANGLAIAAI GLAPQGVMTL CTFVLLASTQ P
Length:491
Mass (Da):53,128
Last modified:February 6, 2007 - v1
Checksum:i5646C6FF251B4DA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94026.1.
RefSeqiWP_011765142.1. NC_008702.1.
YP_932913.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL94026; CAL94026; azo1409.
GeneIDi4609431.
KEGGiazo:azo1409.
PATRICi21011180. VBIAzoSp26047_1434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL94026.1 .
RefSeqi WP_011765142.1. NC_008702.1.
YP_932913.1. NC_008702.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL94026 ; CAL94026 ; azo1409 .
GeneIDi 4609431.
KEGGi azo:azo1409.
PATRICi 21011180. VBIAzoSp26047_1434.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000100795.
KOi K00343.
OMAi MVSSNHL.
OrthoDBi EOG64JFNZ.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiNUON_AZOSB
AccessioniPrimary (citable) accession number: A1K5C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3