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A1K5C1

- NUON_AZOSB

UniProt

A1K5C1 - NUON_AZOSB

Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit NUniRule annotation
    NDH-1 subunit NUniRule annotation
    Gene namesi
    Name:nuoNUniRule annotation
    Ordered Locus Names:azo1409
    OrganismiAzoarcus sp. (strain BH72)
    Taxonomic identifieri62928 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
    ProteomesiUP000002588: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491NADH-quinone oxidoreductase subunit NPRO_0000391101Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi62928.azo1409.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei74 – 9421HelicalUniRule annotationAdd
    BLAST
    Transmembranei106 – 12621HelicalUniRule annotationAdd
    BLAST
    Transmembranei128 – 14821HelicalUniRule annotationAdd
    BLAST
    Transmembranei163 – 18321HelicalUniRule annotationAdd
    BLAST
    Transmembranei206 – 22621HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei272 – 29221HelicalUniRule annotationAdd
    BLAST
    Transmembranei301 – 32121HelicalUniRule annotationAdd
    BLAST
    Transmembranei336 – 35621HelicalUniRule annotationAdd
    BLAST
    Transmembranei379 – 39921HelicalUniRule annotationAdd
    BLAST
    Transmembranei410 – 43021HelicalUniRule annotationAdd
    BLAST
    Transmembranei465 – 48521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 2 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1007.
    HOGENOMiHOG000100795.
    KOiK00343.
    OMAiMVSSNHL.
    OrthoDBiEOG64JFNZ.

    Family and domain databases

    HAMAPiMF_00445. NDH1_NuoN_1.
    InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1K5C1-1 [UniParc]FASTAAdd to Basket

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    MNFVVPDFYP ATAEIFVAVM ALVIMLATTF ARSVARGLAY GLTLVTLIGA    50
    AIITYNTANP RAVTTFSNMF IGDLLGDVLK LLIYFSMAVA LLYGRSYLAD 100
    RKLDKPEYYV LALLMTLGMM VMVTSNHLLS MYIGLELMSL SLYALVAFDR 150
    DSARGTEAAM KYFVLGALAS GLLLYGMSML YGATGTLEIS GIAKSVYNQA 200
    ANDTVLLFGL VFLMAGICFK LGVVPFHMWI PDVYHGANTA VTLIIATAPK 250
    LAAFAMAVRL LVWGLFDVAE HWQTMLMFVA VLSIVLGNLA AIAQTNLKRM 300
    LAYSGISHMG FMLLGLLSGV VDGDPHYALD AYSAAMFYAI SYVIMSLASF 350
    GMIILLSRAG FEAENIDDFK GLNKRSPWFA AMMMFVMFSM AGIPFFIGFF 400
    AKLAVLQAVV AAGYIWVAVV AVLMSVIGAF YYLRLVKVMY FDEPADATPI 450
    QAPAELRVFL SANGLAIAAI GLAPQGVMTL CTFVLLASTQ P 491
    Length:491
    Mass (Da):53,128
    Last modified:February 6, 2007 - v1
    Checksum:i5646C6FF251B4DA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94026.1.
    RefSeqiWP_011765142.1. NC_008702.1.
    YP_932913.1. NC_008702.1.

    Genome annotation databases

    EnsemblBacteriaiCAL94026; CAL94026; azo1409.
    GeneIDi4609431.
    KEGGiazo:azo1409.
    PATRICi21011180. VBIAzoSp26047_1434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM406670 Genomic DNA. Translation: CAL94026.1 .
    RefSeqi WP_011765142.1. NC_008702.1.
    YP_932913.1. NC_008702.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 62928.azo1409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL94026 ; CAL94026 ; azo1409 .
    GeneIDi 4609431.
    KEGGi azo:azo1409.
    PATRICi 21011180. VBIAzoSp26047_1434.

    Phylogenomic databases

    eggNOGi COG1007.
    HOGENOMi HOG000100795.
    KOi K00343.
    OMAi MVSSNHL.
    OrthoDBi EOG64JFNZ.

    Family and domain databases

    HAMAPi MF_00445. NDH1_NuoN_1.
    InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BH72.

    Entry informationi

    Entry nameiNUON_AZOSB
    AccessioniPrimary (citable) accession number: A1K5C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3