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A1K4Q9

- GCH4_AZOSB

UniProt

A1K4Q9 - GCH4_AZOSB

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, azo1197
Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:azo1197
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289473Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo1197.

Structurei

3D structure databases

ProteinModelPortaliA1K4Q9.
SMRiA1K4Q9. Positions 20-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1K4Q9-1 [UniParc]FASTAAdd to Basket

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MNSPLAHAIP DVQNSEDSRQ IAINKVGIKS IRHPVKVSDK NGGVQHTVAN    50
FNMYVGLPHN FKGTHMSRFI EILNSNEREI SVESFEPMLR EMVKRLEAET 100
GHVEMTFPYF INKSAPVSGV QSLMDYEVTF TGEIHEGGRY EFTMKVVVPV 150
TSLCPCSKKI SAYGAHNQRS HVTVTATLND HLWIEDVVQL VEGQASCEVY 200
GLLKRPDEKY VTERAYDNPK FVEDMVRDVA GLLNKEVRID AYAVESENFE 250
SIHNHSAYAL IERDKRIEA 269
Length:269
Mass (Da):30,426
Last modified:February 6, 2007 - v1
Checksum:i0D120E92A3D1F576
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL93814.1.
RefSeqiWP_011764930.1. NC_008702.1.
YP_932701.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93814; CAL93814; azo1197.
GeneIDi4606737.
KEGGiazo:azo1197.
PATRICi21010734. VBIAzoSp26047_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM406670 Genomic DNA. Translation: CAL93814.1 .
RefSeqi WP_011764930.1. NC_008702.1.
YP_932701.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K4Q9.
SMRi A1K4Q9. Positions 20-265.
ModBasei Search...

Protein-protein interaction databases

STRINGi 62928.azo1197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL93814 ; CAL93814 ; azo1197 .
GeneIDi 4606737.
KEGGi azo:azo1197.
PATRICi 21010734. VBIAzoSp26047_1220.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiGCH4_AZOSB
AccessioniPrimary (citable) accession number: A1K4Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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