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A1K4Q9

- GCH4_AZOSB

UniProt

A1K4Q9 - GCH4_AZOSB

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:azo1197
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
ProteomesiUP000002588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000289473Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo1197.

Structurei

3D structure databases

ProteinModelPortaliA1K4Q9.
SMRiA1K4Q9. Positions 20-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1K4Q9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPLAHAIP DVQNSEDSRQ IAINKVGIKS IRHPVKVSDK NGGVQHTVAN
60 70 80 90 100
FNMYVGLPHN FKGTHMSRFI EILNSNEREI SVESFEPMLR EMVKRLEAET
110 120 130 140 150
GHVEMTFPYF INKSAPVSGV QSLMDYEVTF TGEIHEGGRY EFTMKVVVPV
160 170 180 190 200
TSLCPCSKKI SAYGAHNQRS HVTVTATLND HLWIEDVVQL VEGQASCEVY
210 220 230 240 250
GLLKRPDEKY VTERAYDNPK FVEDMVRDVA GLLNKEVRID AYAVESENFE
260
SIHNHSAYAL IERDKRIEA
Length:269
Mass (Da):30,426
Last modified:February 6, 2007 - v1
Checksum:i0D120E92A3D1F576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93814.1.
RefSeqiWP_011764930.1. NC_008702.1.
YP_932701.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93814; CAL93814; azo1197.
GeneIDi4606737.
KEGGiazo:azo1197.
PATRICi21010734. VBIAzoSp26047_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93814.1 .
RefSeqi WP_011764930.1. NC_008702.1.
YP_932701.1. NC_008702.1.

3D structure databases

ProteinModelPortali A1K4Q9.
SMRi A1K4Q9. Positions 20-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 62928.azo1197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL93814 ; CAL93814 ; azo1197 .
GeneIDi 4606737.
KEGGi azo:azo1197.
PATRICi 21010734. VBIAzoSp26047_1220.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiGCH4_AZOSB
AccessioniPrimary (citable) accession number: A1K4Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3