dut

Functionⁱ

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityⁱ

dUTP + H₂O = dUMP + diphosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation

Pathwayⁱ: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

dCTP deaminase (dcd)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)

This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	81	SubstrateUniRule annotation		1

GO - Molecular functionⁱ

dUTP diphosphatase activity Source: UniProtKB-EC
metal ion binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

dUMP biosynthetic process Source: UniProtKB-UniPathway
dUTP metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Nucleotide metabolism
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00610; UER00666.

UniPathwayⁱ

UPA00610; UER00666.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation) Short name: dUTPaseUniRule annotation Alternative name(s): dUTP pyrophosphataseUniRule annotation
Gene namesⁱ	Name:dutUniRule annotation Ordered Locus Names:azo1139
Organismⁱ	Azoarcus sp. (strain BH72)
Taxonomic identifierⁱ	62928 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus
Proteomesⁱ	UP000002588 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000015443	1 – 149	Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST		149

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	62928.azo1139.

STRINGⁱ

62928.azo1139.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1K4K1.
SMRⁱ	A1K4K1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	68 – 70	Substrate bindingUniRule annotation		3
Regionⁱ	85 – 87	Substrate bindingUniRule annotation		3

Sequence similaritiesⁱ

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108Z1K. Bacteria. COG0756. LUCA.
HOGENOMⁱ	HOG000028968.
KEGG Orthology (KO) More...KOⁱ	K01520.
OMAⁱ	GVILINH.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01I6.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07557. trimeric_dUTPase. 1 hit.
HAMAPⁱ	MF_00116. dUTPase_bact. 1 hit.
InterProⁱ	View protein in InterPro IPR029054. dUTPase-like. IPR008181. dUTPase_1. IPR033704. dUTPase_trimeric.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00692. dUTPase. 1 hit.
SUPFAMⁱ	SSF51283. SSF51283. 1 hit.
TIGRFAMsⁱ	TIGR00576. dut. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A1K4K1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHRIDVKLLD PRLKTHPPAY ASAGAAGLDL RACLDAPVLL HPGETTLVPS 
        60         70         80         90        100
GLAIHLADPG LAAMVLPRSG LGHKHGIVLG NLVGLIDSDY QGQVFVSVWN 
       110        120        130        140 
RGRDVFTIQP MERIAQLVVV PVLQVGFNVV DDFAASERGE GGFGSTGKH

Length:149

Mass (Da):15,758

Last modified:February 6, 2007 - v1

Checksum:ⁱB7ED0FA1BEF6E66F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM406670 Genomic DNA. Translation: CAL93756.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011764872.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAL93756; CAL93756; azo1139.
KEGGⁱ	azo:azo1139.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AM406670 Genomic DNA. Translation: CAL93756.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011764872.1. NC_008702.1.

3D structure databases

ProteinModelPortalⁱ	A1K4K1.
SMRⁱ	A1K4K1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	62928.azo1139.

STRINGⁱ

62928.azo1139.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAL93756; CAL93756; azo1139.
KEGGⁱ	azo:azo1139.

Phylogenomic databases

eggNOGⁱ	ENOG4108Z1K. Bacteria. COG0756. LUCA.
HOGENOMⁱ	HOG000028968.
KEGG Orthology (KO) More...KOⁱ	K01520.
OMAⁱ	GVILINH.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01I6.

Enzyme and pathway databases

UniPathwayⁱ	UPA00610; UER00666.

UniPathwayⁱ

UPA00610; UER00666.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07557. trimeric_dUTPase. 1 hit.
HAMAPⁱ	MF_00116. dUTPase_bact. 1 hit.
InterProⁱ	View protein in InterPro IPR029054. dUTPase-like. IPR008181. dUTPase_1. IPR033704. dUTPase_trimeric.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00692. dUTPase. 1 hit.
SUPFAMⁱ	SSF51283. SSF51283. 1 hit.
TIGRFAMsⁱ	TIGR00576. dut. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DUT_AZOSB
Accessionⁱ	A1K4K1Primary (citable) accession number: A1K4K1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	February 6, 2007
	Last modified:	June 7, 2017
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1K4K1 (DUT_AZOSB)

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Deoxyuridine 5'-triphosphate nucleotidohydrolase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dUMP biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: dUMP biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ