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A1K451 (ARLY_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:azo0989
OrganismAzoarcus sp. (strain BH72) [Complete proteome] [HAMAP]
Taxonomic identifier62928 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Argininosuccinate lyase HAMAP MF_00006
PRO_0000321429

Sequences

Sequence LengthMass (Da)Tools
A1K451 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 504177530593CF42

FASTA48052,723
        10         20         30         40         50         60 
MTDTTPSADL GASSQQPAKA WSGRFSEPVS DLVKRYTASV FFDNRMAEQD IRGSLAHAKM 

        70         80         90        100        110        120 
LARQGIIGAQ DLADIERGMA QIKGEIERGE FNWNLDDEDV HLNIEKRLTA LVGDAGKRLH 

       130        140        150        160        170        180 
TGRSRNDQVA TDIRLWLRDA IDQILALIGD FQKNLLDVAE ANAATPMPGF THLQVAQPVT 

       190        200        210        220        230        240 
FGHHLMAYFE MTRRDAERFA DCRKRVNRLP LGSAALAGTS YPIDREFVAR ELGFDEVCYN 

       250        260        270        280        290        300 
SLDAVSDRDF AIEFCAASSL LMTHLSRFSE ELILWMSPRF GFIDLADRFC TGSSIMPQKK 

       310        320        330        340        350        360 
NPDVPELVRG KTGRVNGSLI ALLTLMKGQP LAYNKDNQED KEPLFDTADT VIDTLRIYAD 

       370        380        390        400        410        420 
MITGIRVKAD NMRGALTQGY ATATDLADYL VKKGLPFRDA HEAVALAVRA AEVRGCDLPQ 

       430        440        450        460        470        480 
FSLDELRAAM AHVPGAADKL ADDIFGVLTV EGSLDSRNHI GGTAPAQVLA AVAHARTRLG

« Hide

References

[1]"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72."
Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. expand/collapse author list , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.
Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BH72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406670 Genomic DNA. Translation: CAL93606.1.
RefSeqYP_932493.1. NC_008702.1.

3D structure databases

ProteinModelPortalA1K451.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1K451.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4606660.
GenomeReviewsGene locus azo0989 in contig AM406670_GR.
KEGGazo:azo0989.
PATRIC21010286. VBIAzoSp26047_1007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBA1K451.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycASP62928:AZO0989-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_AZOSB
AccessionPrimary (citable) accession number: A1K451
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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