Reviewed, UniProtKB/Swiss-Prot A1K451 (ARLY_AZOSB)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	azo0989

Organism

Azoarcus sp. (strain BH72) [Complete proteome] [HAMAP]

Taxonomic identifier

62928 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321429

Sequences

	Sequence		Length	Mass (Da)
	A1K451-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 504177530593CF42	FASTA	480	52,723
	10 20 30 40 50 60 MTDTTPSADL GASSQQPAKA WSGRFSEPVS DLVKRYTASV FFDNRMAEQD IRGSLAHAKM 70 80 90 100 110 120 LARQGIIGAQ DLADIERGMA QIKGEIERGE FNWNLDDEDV HLNIEKRLTA LVGDAGKRLH 130 140 150 160 170 180 TGRSRNDQVA TDIRLWLRDA IDQILALIGD FQKNLLDVAE ANAATPMPGF THLQVAQPVT 190 200 210 220 230 240 FGHHLMAYFE MTRRDAERFA DCRKRVNRLP LGSAALAGTS YPIDREFVAR ELGFDEVCYN 250 260 270 280 290 300 SLDAVSDRDF AIEFCAASSL LMTHLSRFSE ELILWMSPRF GFIDLADRFC TGSSIMPQKK 310 320 330 340 350 360 NPDVPELVRG KTGRVNGSLI ALLTLMKGQP LAYNKDNQED KEPLFDTADT VIDTLRIYAD 370 380 390 400 410 420 MITGIRVKAD NMRGALTQGY ATATDLADYL VKKGLPFRDA HEAVALAVRA AEVRGCDLPQ 430 440 450 460 470 480 FSLDELRAAM AHVPGAADKL ADDIFGVLTV EGSLDSRNHI GGTAPAQVLA AVAHARTRLG

References

[1]

"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72." Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A. Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM406670 Genomic DNA. Translation: CAL93606.1.
RefSeq	YP_932493.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1K451.
Genome annotation databases
GeneID	4606660.
GenomeReviews	Gene locus azo0989 in contig AM406670_GR.
KEGG	azo:azo0989.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_AZOSB

Accession

Primary (citable) accession number: A1K451

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)