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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Azoarcus sp. (strain BH72)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:azo0901Imported
OrganismiAzoarcus sp. (strain BH72)Imported
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi62928.azo0901.

Structurei

3D structure databases

ProteinModelPortaliA1K3W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 315Lyase_1InterPro annotationAdd BLAST299
Domaini334 – 448ASL_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF. Bacteria.
COG0015. LUCA.
HOGENOMiHOG000252916.
KOiK01756.
OMAiTQVNPCD.
OrthoDBiPOG091H01RB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiView protein in InterPro
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
PfamiView protein in Pfam
PF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K3W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAAPSALT ALSPLDGRYH GKVEGLRDHF SEHGLIRNRV KVEVEWLKAL
60 70 80 90 100
AADGALAEIA PFSAATIAEL DSVVSAFAPA DGEAVKAIEA TTNHDVKAME
110 120 130 140 150
YWLKKRLGHN AEVMKVSEFI HFACTSEDIN NTSHALMLKA GRDEVLLPAV
160 170 180 190 200
DKVIARFREL AHQLADLPML SRTHGQPASP TTLGKEMANI AARLIRARAQ
210 220 230 240 250
IANVSLTAKF NGAVGNYNAH LSAWPEFDWE GFNKRFIESL GLEFNPYTIQ
260 270 280 290 300
IEPHDAMAEL FDAIGRMNTI LIDACRDIWM YISFGYFKQK LKEGEVGSST
310 320 330 340 350
MPHKVNPIDF ENAEGNLGIA NAVLRHFSEK LPVSRMQRDL TDSTVLRNMG
360 370 380 390 400
VGFGHTVLAL DSALRGLGKL EAEPARLAAD LAECWEVLAE PVQTVMRRFG
410 420 430 440 450
IENPYEQLKA MTRGKGITRE ALQEFIGTLE IPQSERDRLL AMTPASYVGK

AAELARRI
Length:458
Mass (Da):50,500
Last modified:February 6, 2007 - v1
Checksum:i074DA31B82CB430F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93518.1.
RefSeqiWP_011764635.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93518; CAL93518; azo0901.
KEGGiazo:azo0901.

Similar proteinsi

Entry informationi

Entry nameiA1K3W3_AZOSB
AccessioniPrimary (citable) accession number: A1K3W3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported