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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi893ZincUniRule annotation1
Metal bindingi895ZincUniRule annotation1
Metal bindingi904ZincUniRule annotation1
Metal bindingi905ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:azo0893
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003207281 – 909Protein translocase subunit SecAAdd BLAST909

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo0893.

Structurei

3D structure databases

ProteinModelPortaliA1K3V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1K3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISGLLKKLF GSRNDRLIRQ YSQNVRKINA LEPEIAALSD EALRGKTGEF
60 70 80 90 100
RQRLADGATL NDLLPEAFAV VREAGKRVHG MRHFDVQLIG GMVLHDGKIA
110 120 130 140 150
EMRTGEGKTL VATLAAYLNA LPGKGVHVIT VNDYLASRDA EMMGRIYGFL
160 170 180 190 200
GLTTGCNLSR MGHAEKQLAY AADITYGTNN EFGFDYLRDN MVYATGERVQ
210 220 230 240 250
RGLNFAVVDE VDSILIDEAR TPLIISGQAE DHTDLYLKMN QVAPLLKRQE
260 270 280 290 300
GGLDDKDSVI EPGDYTVDLK AHQVLLTEQG HENAEQILVR IGLLPEGAGL
310 320 330 340 350
YEPGNILLVH HLYAALRAHA LYHKDQHYVV QNGEVVIVDE FTGRLMAGRR
360 370 380 390 400
WSDGLHQAVE AKEGVRIQAE NQTLASITFQ NYFRMYGKLA GMTGTADTEA
410 420 430 440 450
FEFHHIYGLE TVVIPTNRPM VRKDENDKVY RTAKEKWEAV IADIADCVKR
460 470 480 490 500
GQPVLVGTTS IETNEYLSGL LNKAKIAHQL LNAKQHDSEA QIVAQAGRPG
510 520 530 540 550
VVTIATNMAG RGTDIVLGGN IEKPVSQVRD DDSVPAAEKE SRIAALREEW
560 570 580 590 600
RKVHEQVIAA GGLHIIGTER HESRRIDNQL RGRSGRQGDP GSSRFYLSLE
610 620 630 640 650
DPLMKIFAGE RLNAIMVRLK MPEGEAIEHG MVTRSLESAQ RKVEQRNFDI
660 670 680 690 700
RKQLLEYDDV ANDQRKVIYQ QRNELLETED ISETIQAMRQ GVLHDLFRTY
710 720 730 740 750
VPVDSVEDQW DIAGLEQALA SDYLLKLPLL EWVKAEPNLD DEAILKRIID
760 770 780 790 800
AGEEAYAAKI AQVDAAAWHQ FERNVMLQSL DTHWREHLAA LDHLRQGIHL
810 820 830 840 850
RGYAQKNPKQ EYKREAFELF ETLLDTVRAD VSKLLMTVQI RTEAQLDEAE
860 870 880 890 900
APPEMENVQY HHADYDEALA AAAASTAETP VQGGPKVGRN DPCPCGSGKK

YKHCHGKLS
Length:909
Mass (Da):101,537
Last modified:February 6, 2007 - v1
Checksum:i139297FBD9FEBAAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93510.1.
RefSeqiWP_011764627.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93510; CAL93510; azo0893.
KEGGiazo:azo0893.
PATRICi21010082. VBIAzoSp26047_0909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93510.1.
RefSeqiWP_011764627.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1K3V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo0893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL93510; CAL93510; azo0893.
KEGGiazo:azo0893.
PATRICi21010082. VBIAzoSp26047_0909.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_AZOSB
AccessioniPrimary (citable) accession number: A1K3V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.