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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi893ZincUniRule annotation1
Metal bindingi895ZincUniRule annotation1
Metal bindingi904ZincUniRule annotation1
Metal bindingi905ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciASP62928:G1GJH-900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:azo0893
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesZoogloeaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003207281 – 909Protein translocase subunit SecAAdd BLAST909

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo0893

Structurei

3D structure databases

ProteinModelPortaliA1K3V5
SMRiA1K3V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 2 hits
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

A1K3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISGLLKKLF GSRNDRLIRQ YSQNVRKINA LEPEIAALSD EALRGKTGEF
60 70 80 90 100
RQRLADGATL NDLLPEAFAV VREAGKRVHG MRHFDVQLIG GMVLHDGKIA
110 120 130 140 150
EMRTGEGKTL VATLAAYLNA LPGKGVHVIT VNDYLASRDA EMMGRIYGFL
160 170 180 190 200
GLTTGCNLSR MGHAEKQLAY AADITYGTNN EFGFDYLRDN MVYATGERVQ
210 220 230 240 250
RGLNFAVVDE VDSILIDEAR TPLIISGQAE DHTDLYLKMN QVAPLLKRQE
260 270 280 290 300
GGLDDKDSVI EPGDYTVDLK AHQVLLTEQG HENAEQILVR IGLLPEGAGL
310 320 330 340 350
YEPGNILLVH HLYAALRAHA LYHKDQHYVV QNGEVVIVDE FTGRLMAGRR
360 370 380 390 400
WSDGLHQAVE AKEGVRIQAE NQTLASITFQ NYFRMYGKLA GMTGTADTEA
410 420 430 440 450
FEFHHIYGLE TVVIPTNRPM VRKDENDKVY RTAKEKWEAV IADIADCVKR
460 470 480 490 500
GQPVLVGTTS IETNEYLSGL LNKAKIAHQL LNAKQHDSEA QIVAQAGRPG
510 520 530 540 550
VVTIATNMAG RGTDIVLGGN IEKPVSQVRD DDSVPAAEKE SRIAALREEW
560 570 580 590 600
RKVHEQVIAA GGLHIIGTER HESRRIDNQL RGRSGRQGDP GSSRFYLSLE
610 620 630 640 650
DPLMKIFAGE RLNAIMVRLK MPEGEAIEHG MVTRSLESAQ RKVEQRNFDI
660 670 680 690 700
RKQLLEYDDV ANDQRKVIYQ QRNELLETED ISETIQAMRQ GVLHDLFRTY
710 720 730 740 750
VPVDSVEDQW DIAGLEQALA SDYLLKLPLL EWVKAEPNLD DEAILKRIID
760 770 780 790 800
AGEEAYAAKI AQVDAAAWHQ FERNVMLQSL DTHWREHLAA LDHLRQGIHL
810 820 830 840 850
RGYAQKNPKQ EYKREAFELF ETLLDTVRAD VSKLLMTVQI RTEAQLDEAE
860 870 880 890 900
APPEMENVQY HHADYDEALA AAAASTAETP VQGGPKVGRN DPCPCGSGKK

YKHCHGKLS
Length:909
Mass (Da):101,537
Last modified:February 6, 2007 - v1
Checksum:i139297FBD9FEBAAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA Translation: CAL93510.1
RefSeqiWP_011764627.1, NC_008702.1

Genome annotation databases

EnsemblBacteriaiCAL93510; CAL93510; azo0893
KEGGiazo:azo0893

Similar proteinsi

Entry informationi

Entry nameiSECA_AZOSB
AccessioniPrimary (citable) accession number: A1K3V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health