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Protein

Cell division protein FtsZ

Gene

FtsZ

Organism
Azoarcus sp. (strain BH72)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361GTPUniRule annotation
Binding sitei138 – 1381GTPUniRule annotation
Binding sitei182 – 1821GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 255GTPUniRule annotation
Nucleotide bindingi105 – 1073GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:FtsZImported
Synonyms:ftsZUniRule annotation
Ordered Locus Names:azo0889Imported
OrganismiAzoarcus sp. (strain BH72)Imported
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi62928.azo0889.

Structurei

3D structure databases

ProteinModelPortaliA1K3V1.
SMRiA1K3V1. Positions 12-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 200188TubulinInterPro annotationAdd
BLAST
Domaini202 – 320119Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiPOG091H02KK.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K3V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIVEKEPT GTIIKVIGIG GAGGNAVDHM IREGVQGVQF ISANTDAQAL
60 70 80 90 100
SRCLASTKIQ LGVTGLGAGS KPEAGRAAAQ ESREQIAAAL EGAHMCFITG
110 120 130 140 150
GMGGGTGTGA APVVAEIAKE MGILCVAVVT KPFDFENRIR VAESGVEELT
160 170 180 190 200
RHVDSLIVVL NDKLLDVFGD DAGFEECFRS ADNVLRSAVG GIAEIINVPG
210 220 230 240 250
LVNVDFQDVR TAMAEMGRAM MGSAEASGMD RARIAAEQAA VSPLLEGTEL
260 270 280 290 300
SGARCVLINI TASKSLKMSE VRDAVKTVQA FAAPEAFVKY GTVFDESMGD
310 320 330 340 350
NIRITVVATG LGTPRAARQP VMQVVQGTGT YGPMGGVDAN PAMPEVFRTG
360 370 380
RGGARTTVDA MASNGMGNYD IPAFLRRQAD
Length:380
Mass (Da):39,472
Last modified:February 6, 2007 - v1
Checksum:i6B415643326E7765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93506.1.
RefSeqiWP_011764623.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93506; CAL93506; azo0889.
KEGGiazo:azo0889.
PATRICi21010074. VBIAzoSp26047_0905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93506.1.
RefSeqiWP_011764623.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1K3V1.
SMRiA1K3V1. Positions 12-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo0889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL93506; CAL93506; azo0889.
KEGGiazo:azo0889.
PATRICi21010074. VBIAzoSp26047_0905.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiPOG091H02KK.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1K3V1_AZOSB
AccessioniPrimary (citable) accession number: A1K3V1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.