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A1K3U3 (MRAY_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:azo0881
OrganismAzoarcus sp. (strain BH72) [Complete proteome] [HAMAP]
Taxonomic identifier62928 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002936

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane339 – 35921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1K3U3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 09D683B38BA056C7

FASTA36238,801
        10         20         30         40         50         60 
MLLELALWLG QDIRGFNVFG YITLRTVLAA LTALAISLTA GPGVIRWLAA KKIGQAVRDD 

        70         80         90        100        110        120 
GPKSHLTKAG TPTMGGALIL IAIGITILLW GDLRNAYVWV TLLVTLGFGA VGWVDDWRKV 

       130        140        150        160        170        180 
VHRDPKGLAS RWKYFWTSAI ALGASIFLGL SATTPAETEL IVPFFKAVAY PLGVYGFIAL 

       190        200        210        220        230        240 
TYFVINGTSH AVNLTDGLDG LAIMPTVMVA GALAIFAYVA GHAGFSKYLG VPYIAGAGEL 

       250        260        270        280        290        300 
AVFCGAICGA GLGFLWFNAY PAEVFMGDVG ALALGAALGT IAVVVRQEIV LFIMGGLFVA 

       310        320        330        340        350        360 
ETLSVMVQVL YFKASGGKRI FRMAPLHHHY ELSGWKETQV VVRFWIITLM LVLFGLSTLK 


LR

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References

[1]"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72."
Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. expand/collapse author list , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.
Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BH72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406670 Genomic DNA. Translation: CAL93498.1.
RefSeqYP_932385.1. NC_008702.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1K3U3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4609292.
GenomeReviewsGene locus azo0881 in contig AM406670_GR.
KEGGazo:azo0881.
PATRIC21010058. VBIAzoSp26047_0897.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
PhylomeDBA1K3U3.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycASP62928:AZO0881-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_AZOSB
AccessionPrimary (citable) accession number: A1K3U3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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