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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:azo0706
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000172991 – 231Biosynthetic peptidoglycan transglycosylaseAdd BLAST231

Interactioni

Protein-protein interaction databases

STRINGi62928.azo0706.

Structurei

3D structure databases

ProteinModelPortaliA1K3B8.
SMRiA1K3B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108VKV. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK03814.
OMAiPINNSMF.
OrthoDBiPOG091H03R6.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K3B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLWRWLGR ALLAAFALLL LWQVWLFAQV AWWRTHNPDS TSFMRLRLDA
60 70 80 90 100
LQEKKPDARL RHTWVPYEQI SIHLKRAVVA AEDDGFVDHE GFDWDGIQRA
110 120 130 140 150
LEKNERKGRP VSGGSTISQQ LAKNLFLSPS RSYFRKAQEA VITVMIEQLW
160 170 180 190 200
SKRRILEVYL NVVEWGNGIF GAEAAARRYY GLPASRLGPA EAARLAVMLP
210 220 230
NPRKYERSFG PRLAAHADRI RGRMAWAEVP P
Length:231
Mass (Da):26,605
Last modified:February 6, 2007 - v1
Checksum:i82CC9D7D488D21C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93323.1.
RefSeqiWP_011764441.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93323; CAL93323; azo0706.
KEGGiazo:azo0706.
PATRICi21009688. VBIAzoSp26047_0719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93323.1.
RefSeqiWP_011764441.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1K3B8.
SMRiA1K3B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo0706.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL93323; CAL93323; azo0706.
KEGGiazo:azo0706.
PATRICi21009688. VBIAzoSp26047_0719.

Phylogenomic databases

eggNOGiENOG4108VKV. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288116.
KOiK03814.
OMAiPINNSMF.
OrthoDBiPOG091H03R6.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTGA_AZOSB
AccessioniPrimary (citable) accession number: A1K3B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 12, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.