Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1K344 (ILVD_AZOSB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:azo0632
OrganismAzoarcus sp. (strain BH72) [Complete proteome] [HAMAP]
Taxonomic identifier62928 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Azoarcus

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_1000000955

Sites

Metal binding1221Iron-sulfur (4Fe-4S) Potential
Metal binding1951Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A1K344 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9CDEFDF8EF1F5EF8

FASTA61665,694
        10         20         30         40         50         60 
MPQYRSRTST AGRNMAGARA LWRATGMKDG DFEKPIIAIA NSFTQFVPGH VHLKDLGQLV 

        70         80         90        100        110        120 
AREIEAAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI ADSVEYMVNA HTADALVCIS 

       130        140        150        160        170        180 
NCDKITPGML MAALRLNIPT IFVSGGPMEA GKVKWEAKII PLDLVDAMVK AADKNCSDEE 

       190        200        210        220        230        240 
VDAIERSACP TCGSCSGMFT ANSMNCLTEA LGLSLPGNGT TLATHADREK LFREAGRRIV 

       250        260        270        280        290        300 
DLAKRYYEKD DATVLPRAIA SFAAFENAIS LDVAMGGSTN TVLHLLAAAK EAGVDFTMKD 

       310        320        330        340        350        360 
IDRISRHVPC LCKVAPAVPD VHIEDVHRAG GIMSILGELD RAGLLNRDVP TVHSKTLGEA 

       370        380        390        400        410        420 
LGRWDIMQAH DKAVFDFFLA APGGVPTQVA FSQNRRWNEL DMDRAKGVIR NKANAFSQDG 

       430        440        450        460        470        480 
GLAVLYGNIA EKGCIVKTAG VDESIWQFTG KARVYESQED AVEGILGEQV QAGDVVVIRY 

       490        500        510        520        530        540 
EGPKGGPGMQ EMLYPTSYLK SRGLGKECAL LTDGRFSGGT SGLSIGHASP EAAMGGAIAL 

       550        560        570        580        590        600 
VEDGDTIEID IPNRRIALAV SDEELARRRA AMEAKGAAAW KPANRERVVS AALQAYAALT 

       610 
TSADTGAVRD ITQVQR

« Hide

References

[1]"Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72."
Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J., Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C., Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J., Weidner S. expand/collapse author list , Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.
Nat. Biotechnol. 24:1385-1391(2006) [PubMed: 17057704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BH72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM406670 Genomic DNA. Translation: CAL93249.1.
RefSeqYP_932136.1. NC_008702.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1K344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4606484.
GenomeReviewsGene locus azo0632 in contig AM406670_GR.
KEGGazo:azo0632.
PATRIC21009530. VBIAzoSp26047_0640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHBG671001.
OMASQDCRWP.
PhylomeDBA1K344.
ProtClustDBPRK12448.

Enzyme and pathway databases

BioCycASP62928:AZO0632-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_AZOSB
AccessionPrimary (citable) accession number: A1K344
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents