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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Azoarcus sp. (strain BH72)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation
Metal bindingi204 – 2041ZincUniRule annotation
Metal bindingi207 – 2071ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 2111ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
PreQ(0) synthaseUniRule annotation
Queuosine biosynthesis protein QueCUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:azo0413
OrganismiAzoarcus sp. (strain BH72)
Taxonomic identifieri62928 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAzoarcus
Proteomesi
  • UP000002588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2282287-cyano-7-deazaguanine synthasePRO_0000336890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62928.azo0413.

Structurei

3D structure databases

ProteinModelPortaliA1K2H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.
OrthoDBiEOG6091HB.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

A1K2H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLPRAVVL LSGGLDSATC LAIARDMGLE TYALSVAYGQ RHAAELTASR
60 70 80 90 100
RVAHALGARE HRVASVSLGE FGGSALTDPA IAVPEDAAPG GIPVTYVPAR
110 120 130 140 150
NTVMLSMALA WAEVLGARHI FVGVNAVDYS GYPDCRPAFI QAFETMANLA
160 170 180 190 200
TKAGVEGHPT TIHAPLIDLS KADIIRRGVA LGVDYGLTVS CYQADDDGRA
210 220
CGRCDACRLR REGFAAAGIA DPTRYQAR
Length:228
Mass (Da):23,928
Last modified:February 6, 2007 - v1
Checksum:iD606FC43C51720DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93030.1.
RefSeqiWP_011764148.1. NC_008702.1.

Genome annotation databases

EnsemblBacteriaiCAL93030; CAL93030; azo0413.
KEGGiazo:azo0413.
PATRICi21009076. VBIAzoSp26047_0414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM406670 Genomic DNA. Translation: CAL93030.1.
RefSeqiWP_011764148.1. NC_008702.1.

3D structure databases

ProteinModelPortaliA1K2H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62928.azo0413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL93030; CAL93030; azo0413.
KEGGiazo:azo0413.
PATRICi21009076. VBIAzoSp26047_0414.

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.
OrthoDBiEOG6091HB.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH72.

Entry informationi

Entry nameiQUEC_AZOSB
AccessioniPrimary (citable) accession number: A1K2H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.