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Protein
Submitted name:

Ecdysone receptor (Isoform A)

Gene

ecr-a

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 260Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Ecdysone receptor (Isoform A)Imported
Gene namesi
Name:ecr-aImported
OrganismiTribolium castaneum (Red flour beetle)Imported
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

IntActiA1JUG3. 1 interactor.
MINTiMINT-5223773.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NXXX-ray2.75E/F/G/H306-549[»]
ProteinModelPortaliA1JUG3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA1JUG3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 260Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
KOiK14034.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR003069. Ecdystd_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR01283. ECDYSTEROIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JUG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAICSGNLG SMDIKHEMIY REDDVLLVKS EPQLHSPCAT GSNGLPAGAG
60 70 80 90 100
SNLLCASNGL VTTLASGSSL NGLTNNVPSN GLSSSGPFSS IGGGISASKR
110 120 130 140 150
QRTDDWLSSP SGNVPPLTPS PGPPSHPYTV ISNGYSSPMS SGSYDPYSPN
160 170 180 190 200
GKIGREDLSP SSLNGYSADS CDSKKKKGPT PRQQEELCLV CGDRASGYHY
210 220 230 240 250
NALTCEGCKG FFRRSITKNA VYQCKYGNNC EIDMYMRRKC QECRLKKCLS
260 270 280 290 300
VGMRPECVVP EVQCAVKRKE KKAQKEKDKP NSTTNGSPDV IKVEPELSDS
310 320 330 340 350
EKTLCNGSKG ISPEQEELIH RLVYFQNEYE HPSEEDVKRI INQPMDGEDQ
360 370 380 390 400
CDVRFRHITE ITILTVQLIV EFAKRLPGFD KLLREDQIAL LKACSSEVMM
410 420 430 440 450
FRMARRYDVQ TDSILFVNNQ PYSRDSYNLA GMGETIEDLL HFCRTMYSMK
460 470 480 490 500
VDNAEYALLT AIVIFSERPA LIEGWKVEKI QEIYLEALRA YVDNRRKPKP
510 520 530 540
GTIFAKLLSV LTELRTLGNQ NSEMCFSLKL KNKKLPPFLA EIWDVDLKT
Length:549
Mass (Da):60,966
Last modified:February 6, 2007 - v1
Checksum:i2FB3FA695B9E4B0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM295015 mRNA. Translation: CAL25730.1.
RefSeqiNP_001107650.1. NM_001114178.1.
NP_001135390.1. NM_001141918.1.
UniGeneiTca.11903.

Genome annotation databases

GeneIDi657515.
KEGGitca:657515.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA1JUG3_TRICA
AccessioniPrimary (citable) accession number: A1JUG3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 5, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources