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A1JTC4

- BGAL_YERE8

UniProt

A1JTC4 - BGAL_YERE8

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Protein
Beta-galactosidase
Gene
lacZ, YE2592
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation
Binds 1 sodium ion per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Substrate By similarity
Metal bindingi209 – 2091Sodium By similarity
Binding sitei209 – 2091Substrate By similarity
Sitei373 – 3731Transition state stabilizer By similarity
Sitei407 – 4071Transition state stabilizer By similarity
Metal bindingi432 – 4321Magnesium 1 By similarity
Metal bindingi434 – 4341Magnesium 1 By similarity
Active sitei477 – 4771Proton donor By similarity
Metal bindingi477 – 4771Magnesium 1 By similarity
Binding sitei477 – 4771Substrate By similarity
Active sitei553 – 5531Nucleophile By similarity
Metal bindingi613 – 6131Magnesium 2 By similarity
Metal bindingi617 – 6171Sodium; via carbonyl oxygen By similarity
Metal bindingi620 – 6201Sodium By similarity
Binding sitei620 – 6201Substrate By similarity
Binding sitei1023 – 10231Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Sodium

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:YE2592
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10501050Beta-galactosidaseUniRule annotation
PRO_0000367014Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE2592.

Structurei

3D structure databases

ProteinModelPortaliA1JTC4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni553 – 5564Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiDPKKPYI.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1JTC4-1 [UniParc]FASTAAdd to Basket

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MTAQQEVKPQ ATPALSQILF RRDWENPQIT QYNRLEAHPP FYSWRHLDAA     50
QNDTPSPQRQ LLNGQWSFSY FTQPESVPDE WVEHDLPEAI SMPVPSNWQL 100
HGYDIPIYTN VQYPIPVDPP RVPQNNPTGC YSYNFTLEPD WILSGQTRII 150
FDGVNSAFYL WCNGRWVGYS QDSRLPAEFD LTPYLKAGNN RIAVLVLRWS 200
DGSYLEDQDM WRMSGIFRDV SLLHKPDIHL RDIHISTHLS PEFSSAHLEV 250
MAAVNIPLLD INNSQVTKAY QIQVQLWLAD SLVASLRQPL GTQPIDERGH 300
YTDRTHLSLR VEHPLLWSAE QPALYRTVVS LLDSQQKLIE AEAYDVGFRQ 350
VAIHQGLLKI NGKAVLIRGV NRHEHHPQTG QAIDEESMLQ DIILMKQHNF 400
NAVRCSHYPN HPLWYRLCDR YGLYVVDEAN IETHGMQPMR RLADDPQWFS 450
AFSERVTRMV QRDRNHPCII IWSLGNESGH GATHDALYRW IKTNDPTRPV 500
QYEGGGANTQ ATDIVCPMYA RVDEDQPFPA VPKWAIKKWI GLPNESRPLI 550
LCEYAHAMGN SFGGFARYWQ AFRQYPRLQG GFVWDWVDQS LTRNDENGQP 600
YWAYGGDFGD SPNDRQFCMN GLVFPDRTPH PCLYEAQCAQ QFFQFSLVST 650
SPLIIKVTSE YLFRNSDNEH LYWRIELAGK SVLEGSFPLD LLPESTQQFS 700
LTERLPAICG PGDLWLNVEV RQVEETPWSP SHHRCAWFQW RLPHSLAVLS 750
RGLSDSATSN NLKLHQDIQH ITVTHQQQHW QFNRQTGLLE QWCVGGENRL 800
LTPLRDQFVR APLDNDIGIS ETTRIDPNAW VERWKKAGIY QLEQRCLSLH 850
ADTLSQAIQI SAEYIYEFAQ EQLLHTHWLY RFDQQGHMTI DVRVQIATSL 900
PSLARVGMCC QLSDIYENVE WLGLGPHENY PDRQLSAQHS HWSQPLDQMH 950
TPYIFPSENG LRCNTSMLSY GNWQLTGQFH FGISRYSTQQ LMAASHQHLL 1000
RSEAGTWLNI DGFHMGVGGD DSWSPSVHAD NLLTNEIYQY QVCWQYKDSI 1050
Length:1,050
Mass (Da):121,234
Last modified:February 6, 2007 - v1
Checksum:i86889BDB17379594
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL12630.1.
RefSeqiYP_001006792.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL12630; CAL12630; YE2592.
GeneIDi4714238.
KEGGiyen:YE2592.
PATRICi18564786. VBIYerEnt11519_2750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL12630.1 .
RefSeqi YP_001006792.1. NC_008800.1.

3D structure databases

ProteinModelPortali A1JTC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393305.YE2592.

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL12630 ; CAL12630 ; YE2592 .
GeneIDi 4714238.
KEGGi yen:YE2592.
PATRICi 18564786. VBIYerEnt11519_2750.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi DPKKPYI.
OrthoDBi EOG6XWV0T.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiBGAL_YERE8
AccessioniPrimary (citable) accession number: A1JTC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi