ID   MTLD_YERE8              Reviewed;         387 AA.
AC   A1JT46;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=YE4147;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the
RT   high pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; AM286415; CAL14163.1; -; Genomic_DNA.
DR   RefSeq; YP_001008392.1; -.
DR   GeneID; 4716541; -.
DR   GenomeReviews; AM286415_GR; YE4147.
DR   KEGG; yen:YE4147; -.
DR   NMPDR; fig|630.2.peg.4072; -.
DR   OMA; A1JT46; VDRIVPN.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR000669; Mannitol_DH_core.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    387       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_1000011820.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   387 AA;  41969 MW;  53D2840A5CE48B2F CRC64;
     MKALHFGAGN IGRGFIGKLL ADAGAQLTFA DVNQPLLDEL NKRKSYQVNV VGEQARVEEV
     KNVSAVNSGS PEVVELIAQA DMVTTAVGPQ ILARIAGTVA QGLVTRHQQG NTRPLNIIAC
     ENMVRGTSQL KQQVFAALPE SEQAWVEQHV GFVDSAVDRI VPPSEAGSTD ILAVTVETFS
     EWIVDGTQFK GQPPQIAGME LTDNLMAFVE RKLFTLNTGH AITAYLGQLA GHQTIRDAIL
     DPAVRQTVKG AMEESGAVLI KRYAFDPLKH AAYIEKILSR FENPYLHDDV ERVGRQPLRK
     LSAGDRLIKP LLGTLEYQLP HNNLVTGIAA AMSYRSEQDP QAQELVELLA KLGPKATLAQ
     ISGLPADSEV VEQAVSVYNA MQDKLAH
//